Coumestrol pre‐treatment improves spatial learning and memory deficits following transient cerebral ischemia recruiting hippocampal GluR2 AMPA receptors
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23418
Abstract: Transient global ischemia is a leading cause of learning and memory dysfunction and induces a pattern of delayed neuronal death in the CA1 subfield of the hippocampus by down‐regulating GluR2 mRNA AMPA receptors in this… read more here.
Keywords: ischemia; ampa receptors; memory deficits; memory ... See more keywords
Mutation in the Sip1 transcription factor leads to a disturbance of the preconditioning of AMPA receptors by episodes of hypoxia in neurons of the cerebral cortex due to changes in their activity and subunit composition. The protective effects of interleukin-10.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.07.019
Abstract: The Sip1 mutation plays the main role in pathogenesis of the Mowat-Wilson syndrome, which is characterized by the pronounced epileptic symptoms. Cortical neurons of homozygous mice with Sip1 mutation are resistant to AMPA receptor activators.… read more here.
Keywords: sip1 mutation; episodes hypoxia; cortical neurons; ampa receptors ... See more keywords
Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.05.011
Abstract: SUMMARY Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by amacrine cells… read more here.
Keywords: glial cells; ampa receptors; glutamate transporters; ller glial ... See more keywords
Hippocampal AMPA receptors mediate the impairment of spatial learning and memory in prenatally stressed offspring rats.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2022.03.032
Abstract: Numerous studies have shown that prenatal stress (PS) induces learning and memory deficits in offspring, yet the specific mechanisms and effective interventions remain limited. Chewing has been known as one of the active coping strategies… read more here.
Keywords: learning memory; memory; spatial learning; hippocampal ampa ... See more keywords
TARPs and AMPA Receptors: Function Follows Form
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.02.040
Abstract: In this issue of Neuron, Ben-Yaacov et al. (2017) dissect the interaction between AMPA receptors and auxiliary (TARP) subunits, revealing essential roles for the receptor transmembrane and cytoplasmic domains, as well as for the TARP extracellular… read more here.
Keywords: ampa; receptors function; tarps ampa; ampa receptors ... See more keywords
Deoxyschizandrin attenuates Aβ1–42-induced cognitive impairments through up-regulation of AMPA receptors in mice
Sign Up to like & getrecommendations! Published in 2018 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2018.09.009
Abstract: Abstract The present study was undertaken to investigate the possible effect of deoxyschizandrin (DSD) on improving cognitive impairment in mice induced by β-amyloid (Aβ). The Aβ1-42 was injected into the hippocampus of male mice and… read more here.
Keywords: cognitive impairments; attenuates induced; induced cognitive; deoxyschizandrin attenuates ... See more keywords
FORTIS: a live-cell assay to monitor AMPA receptors using pH-sensitive fluorescence tags
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01457-w
Abstract: The real-time live fluorescent monitoring of surface AMPA receptors (AMPARs) could open new opportunities for drug discovery and phenotypic screening concerning neuropsychiatric disorders. We have developed FORTIS, a tool based on pH sensitivity capable of… read more here.
Keywords: cell assay; live cell; surface ampars; fortis live ... See more keywords
AMPA receptors and perampanel behind selected epilepsies: current evidence and future perspectives
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2017.1392509
Abstract: ABSTRACT Introduction: The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission, and are critical for synchronization and spread of epileptic activity. Areas covered: AMPA receptor antagonists have been also developed… read more here.
Keywords: epilepsy; ampa; ampa receptor; ampa receptors ... See more keywords
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory
Sign Up to like & getrecommendations! Published in 2018 at "Brain"
DOI: 10.1093/brain/awy253
Abstract: Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), which interacts with voltage-gated potassium channels Kv1.1, and the postsynaptic… read more here.
Keywords: kv1 ampa; ampa receptors; lgi1; plasticity ... See more keywords
α2δ‐1 protein promotes synaptic expression of Ca2+ permeable–AMPA receptors by inhibiting GluA1/GluA2 heteromeric assembly in the hypothalamus in hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15573
Abstract: Glutamate AMPA receptors (AMPARs) lacking GluA2 subunit are calcium permeable (CP‐AMPARs), which are increased in the hypothalamic paraventricular nucleus (PVN) and maintain sympathetic outflow in hypertension. Here, we determined the role of α2δ‐1, an NMDA… read more here.
Keywords: hypertension; glua1 glua2; protein; ampa receptors ... See more keywords
A novel approach for vital visualization and studying of neurons containing Ca2+‐permeable AMPA receptors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15729
Abstract: Calcium‐permeable AMPA receptors (CP‐AMPARs) play a pivotal role in brain functioning in health and disease. They are involved in synaptic plasticity, synaptogenesis, and neuronal circuits development. However, the functions of neurons expressing CP‐AMPARs and their… read more here.
Keywords: neurons containing; ampa receptors; ampars containing; permeable ampa ... See more keywords