Enantiomeric separation and quantification of R/S-amphetamine in serum using semi-automated liquid-liquid extraction and ultra-high performance supercritical fluid chromatography-tandem mass spectrometry.
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DOI: 10.1002/dta.2879
Abstract: The amphetamine molecule contains a chiral center and its enantiomers exhibit differences in pharmacological effects, with the S-enantiomer mediating most of the central nervous system stimulating activity. The majority of prescribed amphetamine consists of the… read more here.
Keywords: quantification amphetamine; enantiomeric separation; amphetamine; separation quantification ... See more keywords
Amphetamine improves rat 5-choice continuous performance test (5C-CPT) irrespective of concurrent low-dose haloperidol treatment
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DOI: 10.1007/s00213-020-05511-1
Abstract: Rationale Cognitive dysfunction mediates functional impairment in patients with schizophrenia, necessitating the timely development of pro-cognitive therapeutics. An important initial step in this process is to establish what, if any, pro-cognitive agents and associated mechanisms… read more here.
Keywords: amphetamine; cpt; choice continuous; continuous performance ... See more keywords
Co-exposure of cannabinoids with amphetamines and biological, behavioural and health outcomes: a scoping review of animal and human studies.
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DOI: 10.1007/s00213-021-05960-2
Abstract: RATIONALE The growing prevalence of psychostimulant (including amphetamine) use and associated health harms, with limited treatment options, present a global challenge. There is an increasing availability and medical applications of cannabinoids, and growing interest in… read more here.
Keywords: amphetamine; scoping review; use; human studies ... See more keywords
Pharmacokinetics, Safety, and Tolerability of SHP465 Mixed Amphetamine Salts After Administration of Multiple Daily Doses in Children Aged 4–5 Years with Attention-Deficit/Hyperactivity Disorder
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DOI: 10.1007/s40263-021-00870-5
Abstract: Given the limited treatment options for younger children with attention-deficit/hyperactivity disorder (ADHD), a clinical study for SHP465 treatment was warranted. We aimed to evaluate the pharmacokinetics, safety, and tolerability of SHP465 mixed amphetamine salts (MAS)… read more here.
Keywords: amphetamine; aged years; children aged; treatment ... See more keywords
Potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity
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DOI: 10.1016/j.bbr.2017.07.028
Abstract: Amphetamine and methylphenidate are known to have stimulatory effect in healthy subjects but not in humans with attention deficit hyperactivity disorder and in rodents with impaired dopamine transporter (DAT) function. This phenomenon is called the… read more here.
Keywords: amphetamine; effect; impaired dopamine; dopamine transporter ... See more keywords
Questioning the predictive validity of the amphetamine-induced hyperactivity model for screening mood stabilizing drugs
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DOI: 10.1016/j.bbr.2019.01.006
Abstract: HighlightsAnimal models are critical for screening new therapies.Amphetamine‐induced hyperactivity (AIH) is a screening model for mood stabilizers.The validity of screening models depends on their response to established treatments.We show that in ICR and black Swiss… read more here.
Keywords: amphetamine; hyperactivity; validity; model ... See more keywords
Using anticipatory and drug-evoked appetitive ultrasonic vocalization for monitoring the rewarding effect of amphetamine in a rat model of drug self-administration
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DOI: 10.1016/j.bbr.2019.112187
Abstract: Measuring ultrasonic vocalizations (USVs) allows studying psychoactive drug use-related affective states in laboratory rats and may help understand changes underlying the progress of addictions. We aimed at finding an effective scheme for amphetamine self-administration training… read more here.
Keywords: self administration; amphetamine; drug; anticipatory drug ... See more keywords
Inhibition of basal and amphetamine-stimulated extracellular signal-regulated kinase (ERK) phosphorylation in the rat forebrain by muscarinic acetylcholine M4 receptors
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DOI: 10.1016/j.brainres.2018.03.019
Abstract: The mitogen-activated protein kinase (MAPK), especially its extracellular signal-regulated kinase (ERK) subfamily, is a group of kinases enriched in the mammalian brain. While ERK is central to cell signaling and neural activities, the regulation of… read more here.
Keywords: amphetamine; acetylcholine; erk phosphorylation; kinase ... See more keywords
An adaptive clinical trial design for cocaine use disorder: Extended-release amphetamine salts for early behavioral intervention non-responders.
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DOI: 10.1016/j.cct.2020.106187
Abstract: BACKGROUND/AIMS Cocaine use disorder (CUD) persists as a major public health problem in the United States. Response to evidence-based behavioral treatment has been shown to be predicted by dopaminergic dysfunction. Amphetamine formulations modulate dopaminergic systems… read more here.
Keywords: intervention; cocaine use; amphetamine; trial ... See more keywords
Synthesis of imprinted styrene-maleic acid functionalized resin for enantio-selective extraction of R-amphetamine
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DOI: 10.1016/j.cej.2018.09.028
Abstract: Abstract This article presents the development of an enantio-selective polymeric resin based on cross-linked styrene-maleic acid copolymer for chiral recognition of R-amphetamine and efficient optical resolution of (±)-amphetamine racemate. In the beginning, a polymerizable R-amphetamine-maleimide… read more here.
Keywords: amphetamine; maleic acid; resin; enantio selective ... See more keywords
False-positive amphetamine results on several drug screening platforms due to mexiletine.
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DOI: 10.1016/j.clinbiochem.2018.05.013
Abstract: OBJECTIVE False-positive urine drug of abuse screening (UDS) results can have serious implications in clinical practice, particularly when confirmation assay results are not immediately available to providers making medical decisions. Often it is not possible… read more here.
Keywords: amphetamine results; amphetamine; drug; false positive ... See more keywords