Multimeric Amphipathic α‐Helical Sequences for Rapid and Efficient Intracellular Protein Transport at Nanomolar Concentrations
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DOI: 10.1002/advs.201800240
Abstract: Abstract An amphipathic leucine (L) and lysine (K)‐rich α‐helical peptide is multimerized based on helix‐loop‐helix structures to maximize the penetrating activities. The multimeric LK‐based cell penetrating peptides (LK‐CPPs) can penetrate cells as protein‐fused forms at… read more here.
Keywords: multimeric cpps; sequences rapid; helical sequences; multimeric amphipathic ... See more keywords
Amphipathic helical peptide-Nile red probes for fluorescence probing of the lipid packing defects and their surrounding membranes on exosomes
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DOI: 10.1038/s41598-025-08534-w
Abstract: Amphipathic helical (AH) peptide-based fluorescent probes were explored for analysis of lipid packing defects (LPDs) in the membrane surface of exosomes. Two kinds of AH peptide sequences, derived from the C-terminal sequence of Apolipoprotein A-I… read more here.
Keywords: amphipathic helical; packing defects; lipid packing; helical peptide ... See more keywords
High-Resolution Structural Studies Elucidate Antiatherogenic and Anti-Inflammatory Properties of Peptides Designed to Mimic Amphipathic α-Helical Domains of Apolipoprotein A-I
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DOI: 10.1177/1934578x19849131
Abstract: Peptides designed to mimic the antiatherogenic and anti-inflammatory properties of apolipoprotein A-I show that although lipid association is required, not all lipid-associating peptides exhibit these properties. Our studies of a series of peptides showed that… read more here.
Keywords: anti inflammatory; designed mimic; peptides designed; amphipathic helical ... See more keywords