Prediction of Amphipathic Helix - Membrane Interactions with Rosetta
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2020.11.380
Abstract: Amphipathic helices have hydrophobic and hydrophilic/charged residues situated on opposite faces of the helix. They can anchor peripheral membrane proteins to the membrane, be attached to integral membrane proteins, or exist as independent peptides. Despite… read more here.
Keywords: amphipathic helix; amphipathic helices; helix; helix membrane ... See more keywords
Ankyrin repeat-containing N-Ank proteins shape cellular membranes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-019-0381-7
Abstract: Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood—mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still… read more here.
Keywords: amphipathic helix; ank proteins; terminal amphipathic; membrane ... See more keywords
Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-10-0473
Abstract: The primary cilium is a nexus for cell signaling and relies on specific protein trafficking for function. The tubby family protein TULP3 transports integral membrane proteins into cilia through interactions with the intraflagellar transport complex-A… read more here.
Keywords: amphipathic helix; domain arl13b; tubby domain; domain ... See more keywords
Ab-Initio Membrane Protein Amphipathic Helix Structure Prediction Using Deep Neural Networks
Sign Up to like & getrecommendations! Published in 2022 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2020.3029274
Abstract: Amphipathic helix (AH)features the segregation of polar and nonpolar residues and plays important roles in many membrane-associated biological processes through interacting with both the lipid and the soluble phases. Although the AH structure has been… read more here.
Keywords: amphipathic helix; structure; prediction; membrane protein ... See more keywords
Prediction of amphipathic helix—membrane interactions with Rosetta
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008818
Abstract: Amphipathic helices have hydrophobic and hydrophilic/charged residues situated on opposite faces of the helix. They can anchor peripheral membrane proteins to the membrane, be attached to integral membrane proteins, or exist as independent peptides. Despite… read more here.
Keywords: amphipathic helix; amphipathic helices; helix; helix membrane ... See more keywords
Dissecting the mechanism of action of actinoporins. Role of the N-terminal amphipathic α-helix in membrane binding and pore activity of sticholysins I and II
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0202981
Abstract: Actinoporins sticholysin I and sticholysin II (St I, St II) are proposed to lyse model and biomembranes via toroidal pore formation by their N-terminal domain. Based on the hypothesis that peptide fragments can reproduce the… read more here.
Keywords: mechanism action; terminal amphipathic; pore; amphipathic helix ... See more keywords
An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201546
Abstract: Amino acid residues 107–125 of RPE65, in concert with a palmitoyl group at C112, form a membrane-sensing amphipathic helix that targets RPE65 to smooth endoplasmic reticulum to acquire its substrate. RPE65 retinol isomerase is an… read more here.
Keywords: amphipathic helix; rpe65; membrane binding; membrane ... See more keywords
An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.78385
Abstract: The nuclear pore complex (NPC) is the central portal for macromolecular exchange between the nucleus and cytoplasm. In all eukaryotes, NPCs assemble into an intact nuclear envelope (NE) during interphase, but the process of NPC… read more here.
Keywords: amphipathic helix; nuclear pore; brl1; biogenesis ... See more keywords