Aggregated amphiphilic antimicrobial peptides embedded in bacterial membranes.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c09931
Abstract: Molecular dynamics (MD) simulations, stochastic optical reconstruction microscopy (STORM) and neutron reflection (NR) are combined to explore how antimicrobial peptides (AMPs) can be designed to promote the formation of nanoaggregates into bacterial membranes and impose… read more here.
Keywords: microscopy; peptides embedded; amphiphilic antimicrobial; aggregated amphiphilic ... See more keywords
Membranolytic Mechanism of Amphiphilic Antimicrobial β-Stranded [KL]n Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092071
Abstract: Amphipathic peptides can act as antibiotics due to membrane permeabilization. KL peptides with the repetitive sequence [Lys-Leu]n-NH2 form amphipathic β-strands in the presence of lipid bilayers. As they are known to kill bacteria in a… read more here.
Keywords: amino acids; mechanism amphiphilic; mechanism; membranolytic mechanism ... See more keywords