Optimal Hydrophobicity and Reorientation of Amphiphilic Peptides Translocating through Membrane.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.08.012
Abstract: Cell-penetrating and some antimicrobial peptides can translocate across lipid bilayers without disrupting the membrane structure. However, the molecular properties required for efficient translocation are not fully understood. We employed the Metropolis Monte Carlo method together… read more here.
Keywords: amphiphilic peptides; hydrophobicity reorientation; optimal hydrophobicity; translocation ... See more keywords
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01782
Abstract: We report the synthesis and antibacterial activities of a series of amphiphilic membrane-active peptides composed, in part, of various nongenetically coded hydrophobic amino acids. The lead cyclic peptides, 8C and 9C, showed broad-spectrum activity against… read more here.
Keywords: small amphiphilic; cyclic peptides; amphiphilic peptides; activity ... See more keywords
Left or Right: How Does Amino Acid Chirality Affect the Handedness of Nanostructures Self-Assembled from Short Amphiphilic Peptides?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b00847
Abstract: Peptide and protein fibrils have attracted an enormous amount of interests due to their relevance to many neurodegenerative diseases and their potential applications in nanotechnology. Although twisted fibrils are regarded as the key intermediate structures… read more here.
Keywords: amphiphilic peptides; chirality; microscopy; handedness ... See more keywords
Inhaler with electrostatic sterilizer and use of cationic amphiphilic peptides may accelerate recovery from COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Biotechniques"
DOI: 10.2144/btn-2020-0042
Abstract: We explore the design of a smart inhaler with electrostatic sterilizer and propose the utilization of cationic amphiphilic peptides, independently or in conjunction with a bronchodilator, for COVID-19 patients to quickly improve wellbeing while maintaining… read more here.
Keywords: amphiphilic peptides; cationic amphiphilic; covid; inhaler electrostatic ... See more keywords
Amphiphilic peptides as novel nanomaterials: design, self-assembly and application
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s166403
Abstract: Designer self-assembling peptides are a category of emerging nanobiomaterials which have been widely investigated in the past decades. In this field, amphiphilic peptides have received special attention for their simplicity in design and versatility in… read more here.
Keywords: amphiphilic peptides; self assembling; design self; application ... See more keywords