End-Sealing of Peptide Nanotubes by Cationic Amphiphilic Polypeptides and Their Salt-Responsive Accordion-like Opening and Closing Behavior.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00153
Abstract: One strategy to prepare phase-separated co-assembly is to use the existing assembly as a platform to architect structures. For this purpose, the edge of a sheet or tube-shaped molecular assembly, which is less hydrophilic than… read more here.
Keywords: cationic amphiphilic; sealing peptide; accordion; end sealing ... See more keywords
Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12010039
Abstract: Polyethyleneimine, poly-L-lysine, chitosan and some others cationic polymers have been thoroughly studied as nucleic acid delivery systems in gene therapy. However, the drug release from these systems proceeds at a very low rate due to… read more here.
Keywords: amphiphilic polypeptides; sirna delivery; polypeptides vegf; delivery ... See more keywords
Amphiphilic Polypeptides Obtained by Post-Polymerization Modification of Poly-l-Lysine as Systems for Combined Delivery of Paclitaxel and siRNA
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041308
Abstract: The development of effective anti-cancer therapeutics remains one of the current pharmaceutical challenges. The joint delivery of chemotherapeutic agents and biopharmaceuticals is a cutting-edge approach to creating therapeutic agents of enhanced efficacy. In this study,… read more here.
Keywords: amphiphilic polypeptides; post polymerization; poly lysine; polymerization modification ... See more keywords
The Length of Hydrophobic Chain in Amphiphilic Polypeptides Regulates the Efficiency of Gene Delivery
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DOI: 10.3390/polym10040379
Abstract: The major challenges of non-viral carriers are low transfection efficiency and high toxicity. To overcome this bottleneck, it is very important to investigate the structure-property-function (transfection efficiency) relationships of polycations. Herein, different length hydrophobic poly(l-leucine)… read more here.
Keywords: poly lysine; amphiphilic polypeptides; block poly; poly ... See more keywords