Improving the Hemocompatibility of Antimicrobial Peptidomimetics through Amphiphilicity Masking Using a Secondary Amphiphilic Polymer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200546
Abstract: Antimicrobial peptidomimetics (AMPMs) have received widespread attention as potentially powerful weapons against antibiotic resistance. However, AMPMs’ membrane disruption mechanism not only brings resistance‐resistant nature, but also nonspecific binding and disruption toward eukaryotic cell membranes, and… read more here.
Keywords: improving hemocompatibility; antimicrobial peptidomimetics; amphiphilic polymer; amphiphilicity ... See more keywords
Effect of drying methods on the solubility and amphiphilicity of room temperature soluble gelatin extracted by microwave-rapid freezing-thawing coupling.
Sign Up to like & getrecommendations! Published in 2021 at "Food chemistry"
DOI: 10.1016/j.foodchem.2021.129226
Abstract: The effect of three drying methods (hot air, freeze and spray drying) on the solubility and amphiphilicity of gelatin were investigated and compared. Results showed spray drying gelatin (SDG) and hot air drying gelatin (HDG)… read more here.
Keywords: amphiphilicity; effect; gelatin; drying methods ... See more keywords
Tuning Supramolecular Polymers' Amphiphilicity via Host-Guest Interfacial Recognition for Stabilizing Multiple Pickering Emulsions.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c13715
Abstract: Supramolecular host-guest chemistry bridging the adjustable amphiphilicity and macromolecular self-assembly is well advanced in aqueous media. However, the interfacial self-assembled behaviors have not been further exploited. Herein, we designed a β-cyclodextrin-grafted alginate/azobenzene-functionalized dodecyl (Alg-β-CD/AzoC12) supra-amphiphilic… read more here.
Keywords: amphiphilicity; pickering emulsions; chemistry; host guest ... See more keywords
Macromolecular-clustered facial amphiphilic antimicrobials
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DOI: 10.1038/s41467-018-07651-7
Abstract: Bacterial infections and antibiotic resistance, particularly by Gram-negative pathogens, have become a global healthcare crisis. We report the design of a class of cationic antimicrobial polymers that cluster local facial amphiphilicity from repeating units to… read more here.
Keywords: amphiphilicity; clustered facial; facial amphiphilicity; macromolecular clustered ... See more keywords
Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03614k
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c7sc03614k
Abstract: We synthesized a panel of conformationally constrained peptides with either α-helix or β-hairpin conformations. We tuned the amphiphilicity of these constrained peptides with different distributions of charged or hydrophobic residues and compared their cellular uptake… read more here.
Keywords: amphiphilicity; conformationally constrained; enhanced cell; constrained peptides ... See more keywords