Fluconazole Non-susceptible Cryptococcus neoformans, Relapsing/Refractory Cryptococcosis and Long-term Use of Liposomal Amphotericin B in an AIDS Patient
Sign Up to like & getrecommendations! Published in 2017 at "Mycopathologia"
DOI: 10.1007/s11046-017-0165-1
Abstract: The treatment of cryptococcosis is hampered by inefficacy or intolerance to the recommended antifungal agents. A patient diagnosed with AIDS had multiple relapses of cryptococcal infection, which became refractory to antifungal agents during the course… read more here.
Keywords: cryptococcus neoformans; use; amphotericin; liposomal amphotericin ... See more keywords
Enhancing the production of amphotericin B by Strepyomyces nodosus in a 50-ton bioreactor based on comparative genomic analysis
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DOI: 10.1007/s13205-021-02844-2
Abstract: Amphotericin, as an important macrolide antibiotic, is synthesized by Streptomyces nodosus. A high-yield S. nodosus ZJB2016050 was obtained by mutagenesis in our lab with the advantages of high yield, short fermentation cycle and few by-products,… read more here.
Keywords: amphotericin; nodosus; metabolism; nodosus atcc14899 ... See more keywords
Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC‐MS/MS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.06.014
Abstract: HIGHLIGHTSFree and liposomal Amphotericin B were effectively separated in rat plasma by solid phase extraction without liposomal breakdown.Liposomal Amphotericin B was quantified by calculating the difference between total and free Amphotericin B.The method was successfully… read more here.
Keywords: rat plasma; amphotericin; phase extraction; liposomal amphotericin ... See more keywords
Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis
Sign Up to like & getrecommendations! Published in 2021 at "Medical Mycology Case Reports"
DOI: 10.1016/j.mmcr.2021.06.003
Abstract: The standard of care for treatment of sino-orbital mucormycosis involves aggressive surgical debridement and liposomal amphotericin, and the roles of adjunctive and topical therapies are less clear. Here we describe a case of severe refractory… read more here.
Keywords: amphotericin; mucormycosis; case; sino ... See more keywords
Treatment With Liposomal Amphotericin B for All Confirmed Cases of Human Visceral Leishmaniasis in Brazil: A Budget Impact Analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Value in health regional issues"
DOI: 10.1016/j.vhri.2020.05.006
Abstract: OBJECTIVES To estimate the budget impact of the expansion of liposomal amphotericin B use for all confirmed cases of visceral leishmaniasis (VL) in Brazil. Currently, the first-line medicine for VL treatment is meglumine antimoniate. Liposomal… read more here.
Keywords: amphotericin; budget impact; analysis; treatment ... See more keywords
Treatment of pulmonary mucormycosis with adjunctive nebulized amphotericin B (MUCONAB trial): Results of an open-label randomized controlled trial.
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DOI: 10.1111/myc.13591
Abstract: BACKGROUND The role of nebulized amphotericin B (NAB) in managing pulmonary mucormycosis (PM) is unknown. METHODS In this open-label trial, we randomized PM subjects to receive either intravenous liposomal amphotericin B (control arm, 3-5 mg/kg/day) alone… read more here.
Keywords: day; nebulized amphotericin; amphotericin; trial ... See more keywords
Auricular leishmaniasis in a child successfully treated with intralesional amphotericin B
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Dermatology"
DOI: 10.1111/pde.15046
Abstract: Cutaneous leishmaniasis (CL) is the most frequent form of leishmaniasis. The auricle is an extremely rare site for CL in the Old World. Auricular CL may be mistaken for other entities, such as relapsing polychondritis… read more here.
Keywords: amphotericin; successfully treated; child successfully; leishmaniasis ... See more keywords
Efficacy, Biodistribution, and Nephrotoxicity of Experimental Amphotericin B-Deoxycholate Formulations for Pulmonary Aspergillosis
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DOI: 10.1128/aac.00489-18
Abstract: ABSTRACT An experimental micellar formulation of 1:1.5 amphotericin B-sodium deoxycholate (AMB:DCH 1:1.5) was obtained and characterized to determine its aggregation state and particle size. The biodistribution, nephrotoxicity, and efficacy against pulmonary aspergillosis in a murine… read more here.
Keywords: biodistribution; amphotericin; pulmonary aspergillosis; liposomal commercial ... See more keywords
Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010779
Abstract: Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin.… read more here.
Keywords: leishmania mexicana; oxidative stress; amphotericin; resistance ... See more keywords
Safe and Effective Delivery of Amphotericin B: A Survey of Patents.
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DOI: 10.2174/1872210511666170105130210
Abstract: BACKGROUND Amphotericin B, designated as the gold standard among antifungal drugs is the only fungicidal effective against systemic fungal infections. But this drug has various pitfalls associated with it, to bypass which various techniques have… read more here.
Keywords: amphotericin; effective delivery; delivery; drug ... See more keywords
Preparation and characterization of liposomes double loaded with amphotericin B and amphotericin B/hydroxypropyl-beta-cyclodextrin inclusion complex.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738509666210310160436
Abstract: BACKGROUND Amphotericin B (AMB) is water-insoluble polyene, which has a broad spectrum of antifungal activity. The hydrophobic drug only exits in the phospholipid bilayer, leading to a low-drug liposomal loading capacity. OBJECTIVES This study is… read more here.
Keywords: amphotericin; liposomes double; double loaded; drug ... See more keywords