In vivo efficacy & resistance prevention of cefiderocol in combination with ceftazidime/avibactam, ampicillin/sulbactam or meropenem using human-simulated regimens versus Acinetobacter baumannii
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DOI: 10.1093/jac/dkad032
Abstract: Abstract Objective Evaluate the in vivo efficacy and resistance prevention of cefiderocol in combination with ceftazidime/avibactam, ampicillin/sulbactam and meropenem using human-simulated regimens (HSR) in the murine infection model. Methods In total, 15 clinical A. baumannii… read more here.
Keywords: resistance; ampicillin sulbactam; cefiderocol; ceftazidime avibactam ... See more keywords
Evaluation of synergistic activity of antibiotic combinations in extensive drug-resistant Acinetobacter species using checkerboard assay.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001639
Abstract: Introduction. Acinetobacter is one of the challenging drug-resistant organisms that can endanger patients' lives if not treated properly.Aim. This study was designed to investigate the activity of three synergistic antimicrobial combinations against extensive drug-resistant Acinetobacter… read more here.
Keywords: acinetobacter; sulbactam plus; antibiotic combinations; activity ... See more keywords
Growth kinetics of multiple Acinetobacter baumannii resistotype after meropenem-based antibiotic combination exposure.
Sign Up to like & getrecommendations! Published in 2022 at "F1000Research"
DOI: 10.12688/f1000research.122221.2
Abstract: Background: Carbapenems are the treatment of choice for multidrug-resistant (MDR) and extensively drug-resistant (XDR) Acinetobacter baumannii infections, but the emergence of carbapenem-resistant A. baumannii (CRAB) has rendered it ineffective in the vast majority of cases. Combination therapy… read more here.
Keywords: growth; combination; ampicillin sulbactam; meropenem ampicillin ... See more keywords
Comparison of the pharmacokinetics of continuous and intermittent infusions of ampicillin-sulbactam in dogs with septic peritonitis.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of veterinary research"
DOI: 10.2460/ajvr.22.08.0139
Abstract: OBJECTIVE To evaluate the time-course of ampicillin-sulbactam and percentage of time that its concentration is above a given MIC (T% > MIC) in dogs with septic peritonitis when delivered as either a continuous infusion (CI)… read more here.
Keywords: septic peritonitis; dogs septic; ampicillin sulbactam; intermittent infusions ... See more keywords
Tackling Intrinsic Antibiotic Resistance in Serratia marcescens with a Combination of Ampicillin/Sulbactam and Phage SALSA
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DOI: 10.3390/antibiotics9070371
Abstract: During the antibiotic crisis, bacteriophages (briefly phages) are increasingly considered as potential antimicrobial pillars for the treatment of infectious diseases. Apart from acquired drug resistance, treatment options are additionally hampered by intrinsic, chromosomal-encoded resistance. For… read more here.
Keywords: combination; phage; ampicillin sulbactam; resistance ... See more keywords
Bone Concentration of Ampicillin/Sulbactam: A Pilot Study in Patients with Osteonecrosis of the Jaw
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph192214917
Abstract: Osteonecrosis of the jaw (ONJ) occurs typically after irradiation of the head and neck area or after the intake of antiresorptive agents. Both interventions can lead to compromised bone perfusion and can ultimately result in… read more here.
Keywords: bone; concentration; osteonecrosis jaw; ampicillin sulbactam ... See more keywords