AMPK activation ameliorates fine particulate matter-induced hepatic injury
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-08624-4
Abstract: Both the epidemiological and animal experimental studies have reported the association between PM 2.5 and respiratory, cardiovascular, and metabolic diseases. However, the study linking PM 2.5 and hepatic injury is few, and the relative mechanism… read more here.
Keywords: bat; ampk activation; induced hepatic; injury ... See more keywords
AntogomiR-451 protects human gastric epithelial cells from ethanol via activating AMPK signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.082
Abstract: The prevention and treatment efficiency of ethanol-induced gastric epithelial injury are not satisfied. We have previously shown that AMP-activated protein kinase (AMPK) activation exerts a pro-survival function in human gastric epithelial cells (GECs). miroRNA-451 ("miR-451")'s… read more here.
Keywords: gastric epithelial; epithelial cells; antagomir 451; ampk activation ... See more keywords
Fake Inhibitors: AMPK Activation Trumps Inhibition.
Sign Up to like & getrecommendations! Published in 2017 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.07.005
Abstract: Protein kinase inhibitors have become increasingly important therapeutic drugs for the treatment of human diseases; however, resistance and off-target effects can limit their use. In this issue of Cell Chemical Biology, Ross et al. (2017) reveal… read more here.
Keywords: inhibitors ampk; ampk activation; biology; fake inhibitors ... See more keywords
Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.08.025
Abstract: Mitochondrial dynamics regulated by mitochondrial fusion and fission maintain mitochondrial functions, whose alterations underline various human diseases. Here, we show that inositol is a critical metabolite directly restricting AMPK-dependent mitochondrial fission independently of its classical… read more here.
Keywords: ampk activation; fission; inositol serves; mitochondrial fission ... See more keywords
4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2016.12.015
Abstract: The estrogenic chemical 4-nonylphenol (NP) is known to impair testicular devolopment and spermatogenesis in rodents. The objective of this study was to explore the effects of NP on autophagy induction and AMPK-mTOR signaling pathway in… read more here.
Keywords: 4ebp1 signaling; p70s6k 4ebp1; ampk activation; sertoli cells ... See more keywords
Adiponectin protects HL-1 cardiomyocytes against rotenone-induced cytotoxicity through AMPK activation.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.10.010
Abstract: The relationship between mitochondrial dysfunction or ER stress with pathogenesis of cardiovascular disease is well documented, but the crosstalk between them in cardiovascular diseases is not clear. Adiponectin (APN) is reported to become a potential… read more here.
Keywords: rotenone; ampk activation; stress; rotenone induced ... See more keywords
Context-dependent AMPK activation distinctly regulates TAp73 stability and transcriptional activity
Sign Up to like & getrecommendations! Published in 2018 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-018-0020-y
Abstract: TAp73, the homologue of the tumour suppressor p53, has dual roles in tumourigenesis: both as a tumour suppressor and as a promoter of tumour growth. We have recently shown that hypoxia, a condition prevalent in… read more here.
Keywords: stabilisation; ampk activation; tap73; activation ... See more keywords
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02795-4
Abstract: AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without affecting downstream targets previously suggested to be involved, such as p70 ribosomal S6… read more here.
Keywords: ampk activation; cardiac hypertrophy; hypertrophy; glcnacylation ... See more keywords
5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05346-5
Abstract: Leukotriene B4 (LTB4) production via the 5-lipoxygenase (5-LO) pathway contributes to the development of insulin resistance in adipose and hepatic tissues, but the role of LTB4 in skeletal muscle is relatively unknown. Here, the authors… read more here.
Keywords: insulin; stress; ampk activation; insulin resistance ... See more keywords
Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64460-z
Abstract: One-carbon metabolism fuels the high demand of cancer cells for nucleotides and other building blocks needed for increased proliferation. Although inhibitors of this pathway are widely used to treat many cancers, their global impact on… read more here.
Keywords: pro respiratory; elicits pro; methotrexate; ampk activation ... See more keywords
AMPK Activation Enhances Neutrophil's Fungicidal Activity in Vitro and Improves the Clinical Outcome of Fusarium solani Keratitis in Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Current Eye Research"
DOI: 10.1080/02713683.2022.2078494
Abstract: Abstract Purpose To determine whether Activated 5'AMP-activated protein kinase (AMPK) activation enhances Fusarium solani (F. solani) fungicidal capacity of neutrophils. Methods The expression of AMPK and phosphorylated-AMPK (p-AMPK) proteins was tested using Western Blot. Plate… read more here.
Keywords: group; ampk activation; fusarium solani; activation enhances ... See more keywords