Imidazo[1,2‐a]pyridine Derivatives as AMPK Activators: Synthesis, Structure–Activity Relationships, and Regulation of Reactive Oxygen Species in Renal Fibroblasts
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DOI: 10.1002/cmdc.202200696
Abstract: Adenosine 5′‐monophosphate activated protein kinase (AMPK) has emerged as a promising target for the discovery of drugs to treat diabetic nephropathy (DN). Herein, a series of imidazo[1,2‐a]pyridines were designed and synthesized. Among them, the active… read more here.
Keywords: reactive oxygen; imidazo pyridine; oxygen species; pyridine derivatives ... See more keywords
Natural AMPK Activators in Cardiovascular Disease Prevention
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DOI: 10.3389/fphar.2021.738420
Abstract: Cardiovascular diseases (CVD), as a life-threatening global disease, is receiving worldwide attention. Seeking novel therapeutic strategies and agents is of utmost importance to curb CVD. AMP-activated protein kinase (AMPK) activators derived from natural products are… read more here.
Keywords: natural ampk; disease; natural products; ampk ... See more keywords