Bidirectional regulation of adenosine 5′‐monophosphate–activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27312
Abstract: Both berberine and metformin are well‐known antihyperglycemic agents for diabetes treatment. Adenosine monophosphate (AMP)‐activated protein kinase (AMPK) activation is often considered as the most important molecular mechanism although the mechanism has been challenged recently. Up… read more here.
Keywords: ampk activity; berberine metformin; activity; glucose concentration ... See more keywords
Manipulation and Measurement of AMPK Activity in Pancreatic Islets.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7598-3_26
Abstract: The role of the energy sensor AMPK-activated protein kinase (AMPK) in the insulin-secreting β-cell remains unclear and a subject of intense research. With this chapter, we aim to provide a detailed description of the methods… read more here.
Keywords: manipulation measurement; measurement ampk; ampk activity; pancreatic islets ... See more keywords
Regulation of AMPK activity by type 10 adenylyl cyclase: contribution to the mitochondrial biology, cellular redox and energy homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03152-y
Abstract: The downregulation of AMP-activated protein kinase (AMPK) activity contributes to numerous pathologies. Recent reports suggest that the elevation of cellular cAMP promotes AMPK activity. However, the source of the cAMP pool that controls AMPK activity… read more here.
Keywords: adenylyl cyclase; ampk activity; activity; biology ... See more keywords
Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.12.027
Abstract: HIGHLIGHTSA&bgr;1–42 impaired spatial learning and memory that was accompanied by decreasing AMPK activity and suppression of the PGC1‐&agr;/FNDC5/BDNF pathway.Moderate treadmill exercise improved spatial learning and memory which was accompanied by increased AMPK activity and up‐regulation… read more here.
Keywords: bgr; ampk activity; learning memory; exercise ... See more keywords
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1695399
Abstract: ABSTRACT The AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by sensing the metabolic status of the cell. AMPK is regulated by phosphorylation and dephosphorylation as a result of changing AMP/ATP levels and by removal… read more here.
Keywords: ampk activity; ubiquitin ligase; kinase; ampk ... See more keywords
Mulberry Fruit Extract Ameliorates Adipogenesis via Increasing AMPK Activity and Downregulating MicroRNA-21/143 in 3T3-L1 Adipocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal food"
DOI: 10.1089/jmf.2019.4654
Abstract: Mulberry (Morus alba L.) fruits have long been used in traditional medicine and as edible berries in many countries. This study investigated the antiadipogenic effect of high hydrostatic pressure mulberry fruit extract (MFE) during 3T3-L1… read more here.
Keywords: fruit extract; ampk activity; mulberry fruit; 3t3 adipocytes ... See more keywords
Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1148611
Abstract: Aim: AMPK is the key regulatory kinase mediating the effect of berberine (BBR) and metformin on metabolic improvement. The present study investigated the mechanism of BBR on AMPK activation at low doses, which was different… read more here.
Keywords: pen2; bbr; lysosomal ampk; ampk activity ... See more keywords
Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats.
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DOI: 10.3920/bm2019.0058
Abstract: This study aimed to evaluate the anti-ageing effects of different strains of lactobacilli putative probiotics on an ageing rat model as induced by D-galactose and a high fat diet. Male Sprague-Dawley rats were fed with… read more here.
Keywords: lactobacilli modulated; ampk activity; modulated ampk; telomere shortening ... See more keywords
Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Exposed to Hypoxic Environment is Regulated by Caveolin-1-dependent AMPK Activity.
Sign Up to like & getrecommendations! Published in 2021 at "International neurourology journal"
DOI: 10.5213/inj.2040444.222
Abstract: Purpose In general, AMP-activated protein kinase (AMPK) has been known to inhibit cell proliferation or promote cell death, but still remains controversial. In this study, we propose the activity of AMPK which inhibits anti-apoptotic B-cell… read more here.
Keywords: ampk activity; expression; bcl expression;