IL‐17A contributes to myocardial ischemic injury by activating NLRP3 inflammasome in macrophages through AMPK&agr;/p38MAPK/ERK1/2 signal pathway in mice
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DOI: 10.1016/j.molimm.2018.12.014
Abstract: Background Acute myocardial infarction (AMI) is followed by an acute inflammation involving inflammasome activation, thereby inducing cardiac dysfunction. Interleukin‐17A (IL‐17A) involves in many inflammatory diseases, but its roles in inflammation following AMI are still obscure.… read more here.
Keywords: myocardial ischemic; ampk agr; p38mapk erk1; agr p38mapk ... See more keywords
AMPK&agr;2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation
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DOI: 10.1161/circresaha.117.312317
Abstract: Rationale: Mitochondrial dysfunction plays an important role in heart failure (HF). However, the molecular mechanisms regulating mitochondrial functions via selective mitochondrial autophagy (mitophagy) are poorly understood. Objective: We sought to determine the role of AMPK… read more here.
Keywords: heart; ampk agr; ampk; pink1 ... See more keywords