Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08585-4
Abstract: Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid synthesis in the liver. However, the upstream regulation of Insig is incompletely understood. Here we report that AMPK interacts with and mediates phosphorylation of Insig.… read more here.
Keywords: insig; induced gene; ampk dependent; gene ... See more keywords
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14812-0
Abstract: The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status that is crucial for the adaptive response to limited energy availability. AMPK is implicated in the regulation of many cellular processes,… read more here.
Keywords: cyclin; ampk dependent; dependent activation; cyclin cdk16 ... See more keywords
Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK‐dependent mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17519
Abstract: Metformin, a well‐known AMPK agonist, has been widely used as the first‐line drug for treating type 2 diabetes. There had been a significant concern regarding the use of metformin in people with cardiovascular diseases (CVDs)… read more here.
Keywords: dependent mechanisms; clinical evidence; ampk dependent; cardiovascular diseases ... See more keywords
AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo7956
Abstract: Mitochondria are dynamic organelles that undergo membrane remodeling events in response to metabolic alterations to generate an adequate mitochondrial network. Here, we investigated the function of mitochondrial fission regulator 1-like protein (MTFR1L), an uncharacterized protein… read more here.
Keywords: mtfr1l; mitochondrial morphology; protein; ampk dependent ... See more keywords
Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010716
Abstract: During periods of energetic stress, Caenorhabditis elegans can execute a developmentally quiescent stage called “dauer”, during which all germline stem cells undergo a G2 cell cycle arrest. In animals that lack AMP-activated protein kinase (AMPK)… read more here.
Keywords: cell; ampk dependent; cell integrity; trafficking pathway ... See more keywords
Kinsenoside Alleviates Alcoholic Liver Injury by Reducing Oxidative Stress, Inhibiting Endoplasmic Reticulum Stress, and Regulating AMPK-Dependent Autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.747325
Abstract: Background: Anoectochilus roxburghii (Orchidaceae) is a traditional Chinese medicinal herb with anti-inflammatory, antilipemic, liver protective, immunomodulatory, and other pharmacological activities. Kinsenoside (KD), which shows protective effects against a variety types of liver damage, is an… read more here.
Keywords: ampk dependent; stress; autophagy; alcoholic liver ... See more keywords
The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.51631
Abstract: Objectives: Mesenchymal Stem/Stromal Cells (MSC) are promising therapeutic tools for inflammatory diseases due to their potent immunoregulatory capacities. Their suppressive activity mainly depends on inflammatory cues that have been recently associated with changes in MSC… read more here.
Keywords: atp synthase; glycolytic switch; dependent glycolytic; ampk dependent ... See more keywords