Polygonatum sibiricum polysaccharide ameliorates neurotoxicity in Alzheimer disease mice by inhibiting endoplasmic reticulum stress and lipid raft formation through AMPK/GSK3β/Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Neurological research"
DOI: 10.1080/01616412.2025.2559431
Abstract: BACKGROUND Polygonatum sibiricum polysaccharide (PSP) is known for its anti-inflammatory and cognitive improvement effects. However, its potential to alleviate neurotoxicity in Alzheimer's diseafse (AD) has not been thoroughly explored. This study aims to investigate the… read more here.
Keywords: mice; gsk3 nrf2; lipid raft; ampk gsk3 ... See more keywords
Impressic Acid Attenuates the Lipopolysaccharide-Induced Inflammatory Response by Activating the AMPK/GSK3β/Nrf2 Axis in RAW264.7 Macrophages
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DOI: 10.3390/ijms22020762
Abstract: Inflammatory diseases are caused by excessive inflammation from pro-inflammatory mediators and cytokines produced by macrophages. The Nrf2 signaling pathway protects against inflammatory diseases by inhibiting excessive inflammation via the regulation of antioxidant enzymes, including HO-1… read more here.
Keywords: inflammation; ampk gsk3; gsk3 nrf2; gsk3 ... See more keywords