Neuregulin 4 Attenuates Podocyte Injury and Proteinuria in Part by Activating AMPK/mTOR‐Mediated Autophagy in Mice
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30634
Abstract: In this study, we investigate the effect of neuregulin 4 (NRG4) on podocyte damage in a mouse model of diabetic nephropathy (DN) and we elucidate the underlying molecular mechanisms. In vivo experiments were conducted using… read more here.
Keywords: ampk mtor; mice; podocyte injury; nrg4 intervention ... See more keywords
α‐enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22603
Abstract: The α‐enolase (ENO1) plays pivotal roles in several types of cancer, but its clinical significance, functional role, and possible mechanism in colorectal cancer (CRC) have remained unclear. Expression level of ENO1 in CRC tissues was… read more here.
Keywords: mtor pathway; ampk mtor; mtor; eno1 ... See more keywords
SerpinB1a induces hepatopulmonary syndrome by promoting CTSG/AMPK/mTOR pathway-mediated mitophagy
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-025-10082-y
Abstract: Mitophagy, as an important mechanism for selective removal of damaged mitochondria in cells, plays a crucial role in upholding cellular homeostasis. Mounting evidence suggests that autophagy is associated with lung disease. However, the potential molecular… read more here.
Keywords: ampk mtor; serpinb1a; hps; hepatopulmonary syndrome ... See more keywords
Shear Stress Induces Phenotypic Modulation of Vascular Smooth Muscle Cells via AMPK/mTOR/ULK1-Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0505-1
Abstract: Phenotypic modulation of vascular smooth muscle cells (VSMCs) is involved in the pathophysiological processes of the intracranial aneurysms (IAs). Although shear stress has been implicated in the proliferation, migration, and phenotypic conversion of VSMCs, the… read more here.
Keywords: stress; ampk mtor; shear stress; phenotypic modulation ... See more keywords
High glucose downregulates the effects of autophagy on osteoclastogenesis via the AMPK/mTOR/ULK1 pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.052
Abstract: Diabetes is a chronic disease that disrupts the balance between bone formation and bone desorption, which can lead to osteoporosis, increasing the risk of fracture. However, compared with osteoblasts, the biological effects of hyperglycemia on… read more here.
Keywords: mtor ulk1; microscopy; ampk mtor; autophagy osteoclastogenesis ... See more keywords
Artesunate induces autophagy dependent apoptosis through upregulating ROS and activating AMPK-mTOR-ULK1 axis in human bladder cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109273
Abstract: Artesunate is a kind of derivative of artemisinin, which possesses potent anti-cancer effect in addition to its anti-malarial property. And autophagy was a highly conserved process, exerting a double-edged effect in cancer cell survival. Besides,… read more here.
Keywords: bladder cancer; apoptosis; ampk mtor; cancer cells ... See more keywords
Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2017.01.010
Abstract: &NA; Autophagy and apoptosis are commonly involved in the dopaminergic neuron damage in the pathogenesis of Parkinson's disease. Recently, the autophagy pathway is thought to be critical to the process of PD. Therefore, the regulation… read more here.
Keywords: ohda induced; inhibition; ampk mtor; cell ... See more keywords
Ginsenoside Rb1 ameliorates autophagy via the AMPK/mTOR pathway in renal tubular epithelial cells in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.060
Abstract: Although ginsenoside Rb1 (G-Rb1) has exerted an inhibitory effect on renal fibrosis and progression of chronic kidney disease (CKD), its mechanism remains unknown. This study aims to explore the anti-fibrosis effect of G-Rb1 in unilateral… read more here.
Keywords: treatment; ampk mtor; effect; ginsenoside rb1 ... See more keywords
Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114772
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Cyclocarya paliurus (CP) is a traditional Chinese herb and possesses a variety of biological activities including anti-hyperglycemia, anti-hyperlipidemia, antioxidant and anti-inflammation. Arjunolic acid (AA) is an abundant and bioactive ingredient in CP that… read more here.
Keywords: mtor regulated; regulated autophagy; autophagy pathway; ampk mtor ... See more keywords
FTY720 inhibits the activation of pancreatic stellate cells by promoting apoptosis and suppressing autophagy via the AMPK/mTOR pathway
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.12.019
Abstract: Aims: Pancreatic stellate cells (PSCs) play a critical role in the development of pancreatic fibrosis. Any agents that can affect PSC activation could become potential candidates for treating pancreatic fibrosis. FTY720 can attenuate chronic pancreatic… read more here.
Keywords: mtor pathway; apoptosis; ampk mtor; activation ... See more keywords
Activation of AMPK/mTOR-driven autophagy and inhibition of NLRP3 inflammasome by saxagliptin ameliorate ethanol-induced gastric mucosal damage.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119743
Abstract: AIMS Saxagliptin, a selective/potent dipeptidyl peptidase-4 inhibitor, has revealed remarkable anti-inflammatory features in murine models of nephrotoxicity, hepatic injury, and neuroinflammation. However, its potential effect on ethanol-induced gastric mucosal injury has not been examined. Hence,… read more here.
Keywords: gastric mucosal; ampk mtor; mtor; ethanol induced ... See more keywords