NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer.
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DOI: 10.1016/j.canlet.2021.06.029
Abstract: Non-SMC condensin I complex subunit D2 (NCAPD2) is one of the three non-SMC subunits in condensin I. Previous studies have shown that NCAPD2 plays an important role in the chromosome condensation and segregation. However, its… read more here.
Keywords: ncapd2 inhibits; mtorc1 pathway; ampk mtorc1; colorectal cancer ... See more keywords
Sophoricoside ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy
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DOI: 10.1042/bsr20200661
Abstract: Abstract Aim: The study aims to evaluate protective effects of sophoricoside (Sop) on cardiac hypertrophy. Meanwhile, the potential and significance of Sop should be broadened and it should be considered as an attractive drug for… read more here.
Keywords: hypertrophy; sop; cardiac hypertrophy; ameliorates cardiac ... See more keywords
Atractyloside Protect Mice Against Liver Steatosis by Activation of Autophagy via ANT-AMPK-mTORC1 Signaling Pathway
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DOI: 10.3389/fphar.2021.736655
Abstract: Objective: Adenine nucleotide translocase (ANT) can transport ADP from cytoplasm to mitochondrial matrix and provide raw materials for ATP synthesis by oxidative phosphorylation. Dysfunction of ANT leads to limitation of ADP transport and decrease of… read more here.
Keywords: atr; ampk mtorc1; signaling pathway; mice ... See more keywords