Lycopene Ameliorates Polycystic Ovary Syndrome in Rats by Inhibiting Ovarian Ferroptosis Through Activation of the AMPK/Nrf2 Pathway
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DOI: 10.1002/jbt.70158
Abstract: Lycopene (LYC) is an extremely powerful antioxidant with the potential to treat a range of diseases and to inhibit ferroptosis. This research aims to elucidate how LYC impacts polycystic ovarian syndrome (PCOS) and the action… read more here.
Keywords: ampk nrf2; ferroptosis; pcos; nrf2 pathway ... See more keywords
β-Hydroxyisovalerylshikonin regulates macrophage polarization via the AMPK/Nrf2 pathway and ameliorates sepsis in mice
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DOI: 10.1080/13880209.2022.2046111
Abstract: Abstract Context The potential anti-inflammatory bioactivities of β-hydroxyisovalerylshikonin (β-HIVS) remain largely unknown. Objective This study investigated the anti-inflammatory effects and underlying mechanisms of β-HIVS. Materials and methods RAW 264.7 cells stimulated with LPS (100 ng/mL) for… read more here.
Keywords: ampk nrf2; macrophage polarization; nrf2 pathway; mice ... See more keywords
Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice
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DOI: 10.1155/2022/2297268
Abstract: Objective Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) commonly coexist and act synergistically to drive adverse clinical outcomes. This study is aimed at investigating the effects of exercise intervention and oral hypoglycaemic… read more here.
Keywords: ampk nrf2; stress; oxidative stress; hepatocyte apoptosis ... See more keywords
Luteolin Protects Chondrocytes from H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating AMPK-Nrf2 Signaling
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DOI: 10.1155/2022/5635797
Abstract: Osteoarthritis (OA) is a chronic degenerative disease featured by cartilage erosion and inflammation. Luteolin, a member of the flavonoid family, has been shown to exert anti-inflammatory and antioxidative activities. However, the potential biological effects and… read more here.
Keywords: luteolin; h2o2 induced; ampk nrf2; protects chondrocytes ... See more keywords
Abstract 4455: Metabolic stress induces a double positive feedback loop between AMPK and p62 conferring dual activation of AMPK and NRF2 to synergize antioxidant defense
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DOI: 10.1158/1538-7445.am2024-4455
Abstract: Co-occurring mutations in KEAP1 in LKB1-mutant NSCLC activate NRF2 to compensate losing LKB1-AMPK activity during metabolic adaptation and survival. Here, we investigated the regulatory crosstalk between LKB1-AMPK and KEAP1-NRF2 pathways during metabolic stress. We found… read more here.
Keywords: positive feedback; ampk; ampk nrf2; metabolic stress ... See more keywords
Activation of the AMPK/Nrf2 pathway ameliorates LPS-induced acute lung injury by inhibiting oxidative stress and reducing inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cardiothoracic Surgery"
DOI: 10.1186/s13019-024-03020-2
Abstract: Numerous diseases-related acute lung injury (ALI) contributed to high mortality. Currently, the therapeutic effect of ALI was still poor. The detailed mechanism of ALI remained elusive and this study aimed to elucidate the mechanism of… read more here.
Keywords: lung; lung injury; ampk nrf2; injury ... See more keywords
Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway
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DOI: 10.1371/journal.pone.0296792
Abstract: Chronic intermittent hypoxia (CIH) may play an important role in the development of diabetic cardiomyopathy (DCM). However, the exact mechanism of CIH-induced myocardial injury in DCM remains unclear. In vivo, the db/db mice exposed to… read more here.
Keywords: diabetic cardiomyopathy; chronic intermittent; ampk nrf2; lkb1 ampk ... See more keywords
The Implication of Oxidative Stress and AMPK-Nrf2 Antioxidative Signaling in Pneumonia Pathogenesis
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DOI: 10.3389/fendo.2020.00400
Abstract: It is widely recognized that chemical, physical, and biological factors can singly or synergistically evoke the excessive production of oxidative stress in pulmonary tissue that followed by pulmonary lesions and pneumonia. In addition, metabolic and… read more here.
Keywords: metabolic endocrine; ampk nrf2; implication; oxidative stress ... See more keywords
Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01038
Abstract: Metformin has effective therapeutic effects in anti-tumor and anti-fibrotic diseases. However, how the antifibrotic effect of metformin in the eye and how it is transferred are still unclear. Here, the eye drop of metformin treatment… read more here.
Keywords: via activating; surgery; fibrosis; activating ampk ... See more keywords
Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway
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DOI: 10.3389/fphar.2025.1526623
Abstract: Introduction Chondrocyte ferroptosis is an important component of the pathogenesis of osteoarthritis. Paeonol, the main pharmacologically active ingredient of the Paeonia suffruticosa Andrews, is a natural radical scavenger with potent biological activities, including antioxidant, anti-inflammatory,… read more here.
Keywords: nrf2 gpx4; inflammation chondrocytes; ampk nrf2; ferroptosis ... See more keywords
Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway
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DOI: 10.3389/fphar.2025.1527316
Abstract: Background Ferroptosis is a critical factor in the impairment of osteoblast function in osteoporosis. Metformin (Met), a biguanide antidiabetic drug, has demonstrated anti-osteoporotic effects and has been confirmed to exert therapeutic benefits in diabetic osteoporosis… read more here.
Keywords: ampk nrf2; dop; ferroptosis; nrf2 pathway ... See more keywords