AMPK variant, a candidate of novel predictor for chemotherapy in metastatic colorectal cancer: A meta‐analysis using TRIBE, MAVERICC and FIRE3
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32261
Abstract: AMP‐activated protein kinase (AMPK) is a key sensor of energy homeostasis and regulates cell metabolism, proliferation and chemotherapy/radiotherapy sensitivities. This study aimed to explore the relationship between the AMPK pathway‐related single nucleotide polymorphisms (SNPs) and… read more here.
Keywords: chemotherapy; ampk pathway; cancer; meta analysis ... See more keywords
Antagonistic effects of nano-selenium on broilers hepatic injury induced by Cr(VI) poisoning in AMPK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-08501-0
Abstract: Cr (chromium, with common valence states of III and VI) is one of the common broiler feed additives. Liver injury and metabolic disorders could be caused by Cr(VI) (hexavalent chromium) poisoning in broilers. Oxidative damage… read more here.
Keywords: poisoning broilers; expression; nano selenium; injury ... See more keywords
Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.11.002
Abstract: Multiple Myeloma (MM) is an incurable malignancy of terminally differentiated plasma cells, which are predominantly localized in the bone marrow. Myeloid-derived suppressor cells (MDSC) are described to promote MM progression by immunosuppression and induction of… read more here.
Keywords: suppressor cells; derived suppressor; myeloma; multiple myeloma ... See more keywords
The mTORC1/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice.
Sign Up to like & getrecommendations! Published in 2022 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2022.101922
Abstract: PURPOSE - The liver regulates lipid metabolism. Decreasing mTOR (mechanistic target of rapamycin complex 1) and enhancing AMPK (AMP-activated protein kinase) help degrade hepatic diet-induced accumulated lipids. Therefore, the glucagon-like peptide type 1 receptor agonist… read more here.
Keywords: effects semaglutide; obese mice; mtorc1 ampk; receptor agonist ... See more keywords
d-Limonene protects PC12 cells against corticosterone-induced neurotoxicity by activating the AMPK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2019.05.001
Abstract: The stress-induced hormone corticosterone initiates oxidative stress and inflammatory responses, culminating in cell apoptosis and neurological changes. We assessed the effects of d-Limonene on a PC12 cellular model of corticosterone-induced neurotoxicity, and whether these effects… read more here.
Keywords: corticosterone; limonene; corticosterone induced; ampk pathway ... See more keywords
Chlorantraniliprole induces adipogenesis in 3T3-L1 adipocytes via the AMPKα pathway but not the ER stress pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2019.125953
Abstract: Flubendiamide, a ryanoid family insecticide, has been linked to elevated adipogenesis. However, the influence on adipogenesis of chlorantraniliprole, another widely-used ryanoid-class insecticide in agriculture, remains unknown. Therefore, the influence of chlorantraniliprole on adipogenesis was studied… read more here.
Keywords: adipogenesis; chlorantraniliprole induces; ampk pathway; pathway stress ... See more keywords
Proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves regulate lipid metabolism and glucose consumption by activating AMPK pathway in HepG2 cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2016.12.030
Abstract: Abstract The increasing rate of hyperlipidemia has drawn great attention and natural products may play a potential role in prevention of these disorders. Chinese bayberry leaves proanthocyanidin (BLPs) with epigallocatechin-3-O-gallate (EGCG) as its terminal and… read more here.
Keywords: ampk pathway; chinese bayberry; hepg2 cells; glucose consumption ... See more keywords
IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117997
Abstract: AIMS Non-alcoholic fatty liver disease (NAFLD) characterized by excessive hepatic fat deposition is an increasing public health issue worldwide. Insulin resistance is a pivotal factor in NAFLD progression. Studies have found that IGFBP5 was related… read more here.
Keywords: insulin; activating ampk; non alcoholic; igfbp5 ... See more keywords
Activation of AMPK pathway compromises Rab11 downregulation-mediated inhibition of Schwann cell proliferation in a Glut1 and Glut3-dependent manner
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134762
Abstract: Rab11, a small GTPase, is an important protein in the regulation of intracellular plasma membrane trafficking. Schwann cells are the main cells of peripheral nerves and knockdown of Rab11 in these cells inhibits the formation… read more here.
Keywords: glut1 glut3; cell proliferation; activation ampk; cell ... See more keywords
γ-Mangostin ameliorates free fatty acid-induced lipid accumulation via the SIRT1/LKB1/AMPK pathway in HepG2 and L02 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b05632
Abstract: Lipid accumulation is a typical characteristic of nonalcoholic fatty liver disease (NAFLD). The inhibition of lipid accumulation is regarded as a potential treatment for NAFLD. In this study, we investigated the effects of γ-mangostin or… read more here.
Keywords: accumulation; lipid accumulation; sirt1 lkb1; fatty acid ... See more keywords
Lupeol triggers oxidative stress, ferroptosis, apoptosis and restrains inflammation in nasopharyngeal carcinoma via AMPK/NF-κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2072328
Abstract: Abstract Objective Nasopharyngeal carcinoma is a malignant tumor with high incidence in Asia. This study investigated the anti-tumor capacities of lupeol in nasopharyngeal carcinoma. Methods CCK-8 assay was employed to select the suitable concentration and… read more here.
Keywords: nasopharyngeal carcinoma; apoptosis; oxidative stress; ampk pathway ... See more keywords