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   Articles with "ampk pgc" as a keyword



Activation of AMPK-PGC-1α pathway ameliorates peritoneal dialysis related peritoneal fibrosis in mice by enhancing mitochondrial biogenesis

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recommendations! Published in 2022 at "Renal Failure"

DOI: 10.1080/0886022x.2022.2126789

Abstract: Abstract Background The pathogenesis of peritoneal dialysis (PD)-related peritoneal fibrosis (PF) is not clearly understood, and current treatment options are limited. Methods In this study, the effect of PD-related PF on mitochondrial biogenesis was investigated,… read more here.

Keywords: mitochondrial biogenesis; ampk pgc; pgc pathway; activation ampk ... See more keywords

The activation of AMPK/PGC-1α/GLUT4 signaling pathway through early exercise improves mitochondrial function and mitigates ischemic brain damage

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recommendations! Published in 2024 at "NeuroReport"

DOI: 10.1097/wnr.0000000000002048

Abstract: Mitochondria play a crucial role in maintaining cellular energy supply and serve as a source of energy for repairing nerve damage following a stroke. Given that exercise has the potential to enhance energy metabolism, investigating… read more here.

Keywords: mitochondrial function; function; pgc glut4; ampk pgc ... See more keywords

CAMKK2 restored mitochondrial dynamics homeostasis to alleviate pulmonary fibrosis via AMPK/PGC-1α signaling pathway in lung fibroblasts

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recommendations! Published in 2025 at "Molecular Medicine"

DOI: 10.1186/s10020-025-01373-5

Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by aberrant fibroblast activation and extracellular matrix deposition. Emerging evidence implicates mitochondrial dysfunction in IPF pathogenesis. Although CAMKK2 has been implicated in mitochondrial function associated… read more here.

Keywords: lung fibroblasts; pulmonary fibrosis; camkk2; ampk pgc ... See more keywords
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Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1α Pathway in vivo and in vitro

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recommendations! Published in 2021 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2021.636172

Abstract: The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present study investigated the neuroprotective potential of quercetin, a natural AMPK activator. Streptozotocin (STZ)-induced… read more here.

Keywords: pgc pathway; ampk pgc; quercetin;

Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.991421

Abstract: Background: Insufficient neuronal mitochondrial bioenergetics supply occurs after spinal cord injury (SCI), leading to neuronal apoptosis and impaired motor function. Previous reports have shown that photobiomodulation (PBM) could reduce neuronal apoptosis and promote functional recovery,… read more here.

Keywords: tfam pathway; ampk pgc; mitochondrial bioenergetics; pbm ... See more keywords

Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1α/Apoptosis Signaling Pathway

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recommendations! Published in 2022 at "Antioxidants"

DOI: 10.3390/antiox11081465

Abstract: Myocardial infarction (MI) refers to the death of cardiomyocytes triggered by a lack of energy due to myocardial ischemia and hypoxia, and silent mating type information regulation 2 homolog 3 (SIRT3) plays an essential role… read more here.

Keywords: ampk pgc; myocardial infarction; apoptosis; sirt3 ... See more keywords

Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1α Pathway

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recommendations! Published in 2022 at "Pharmaceuticals"

DOI: 10.3390/ph15040469

Abstract: Pharmacological activation of adaptive thermogenesis to increase energy expenditure is considered to be a novel strategy for obesity. Peroxisome-proliferator-activated receptor γ co-activator-1α (PGC-1α), which serves as an inducible co-activator in energy expenditure, is highly expressed… read more here.

Keywords: adipose thermogenesis; ampk pgc; induced obesity; obesity ... See more keywords