AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis.
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DOI: 10.1158/0008-5472.can-22-2595
Abstract: Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC-variants) are associated with impaired DNA damage repair and increased melanoma risk. MC1R signaling is critically dependent on palmitoylation, primarily mediated… read more here.
Keywords: rhc; phosphorylates zdhhc13; melanomagenesis; mc1r ... See more keywords