Therapeutic Effect of LEV in a Propionic Acid‐Induced Autism Model via AMPK/SIRT1 Pathway
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.70055
Abstract: In this study, we aimed to evaluate the therapeutic effect of levetiracetam (LEV), an antiepileptic drug used in the treatment of both focal and generalized epilepsy, in a propionic acid (PPA)‐induced autism model by assessing… read more here.
Keywords: propionic acid; ampk sirt1; autism model; therapeutic effect ... See more keywords
Apoptotic extracellular vesicles alleviate Pg-LPS induced inflammation of macrophages via AMPK/SIRT1/NF-κB pathway and inhibit adjacent osteoclasts formation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontology"
DOI: 10.1002/jper.21-0657
Abstract: BACKGROUND Periodontitis is caused by the imbalance of anti-bacteria immune response and excessive inflammation whereas macrophages play an important role in inflammation. Thus, it is critical for finding efficient anti-inflammatory strategies to alleviate periodontal inflammation… read more here.
Keywords: inflammation; sirt1 pathway; ampk sirt1; osteoclasts formation ... See more keywords
Yinchen lipid-lowering tea attenuates lipid deposition in a fatty liver model by regulating mitochondrial dysfunction through activation of AdipoR1/AMPK/SIRT1 signaling
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DOI: 10.1007/s13205-024-04204-2
Abstract: This study investigated the ameliorative effects of Yinchen lipid-lowering tea (YCLLT) on Non-alcoholic fatty liver disease (NAFLD), the specific mechanism involved was also studied. We modeled hepatocellular steatosis with HepG2 cells and intervened with different… read more here.
Keywords: ampk sirt1; deposition; yinchen lipid; model ... See more keywords
The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.08.149
Abstract: Diabetic nephropathy (DN) with high morbidity and mortality is one of the most severe diabetes complications and affects nearly one-third of people with diabetes. Our present experiment was designed to assess the potential therapeutic of… read more here.
Keywords: sirt1; signaling axis; pgc signaling; pgc ... See more keywords
Gut-Derived Metabolites from Dietary Tryptophan Supplementation Quench Intestinal Inflammation through the AMPK-SIRT1-Autophagy Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05381
Abstract: Tryptophan has drawn wide attention due to its involvement in improving intestinal immune defense directly and indirectly by regulating metabolic pathways. The study aims to elucidate the potential modulating roles of tryptophan to protect against… read more here.
Keywords: inflammation; ampk sirt1; tryptophan; sirt1 autophagy ... See more keywords
Wheat Germ Active Peptide RPPSFF Alleviates Age-Related Osteoporosis through the YY1/AMPK/SIRT1 Pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c07411
Abstract: Wheat germ-derived bioactive peptides have attracted substantial attention for their antioxidant and immunomodulatory properties. However, their potential roles and mechanisms in mitigating osteoporosis remain unclear. This study investigated the antiosteoporotic effects of RPPSFF (RPP), a… read more here.
Keywords: sirt1 pathway; ampk sirt1; yy1 ampk; wheat germ ... See more keywords
Bufei Yishen formula alleviates airway epithelial cell senescence in COPD by activating AMPK-Sirt1-FoxO3a pathway and promoting autophagy
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DOI: 10.1038/s41598-025-00746-4
Abstract: The Bufei Yishen formula (BYF) has traditionally been employed to treat patients with COPD, demonstrating significant effectiveness. However, the underlying mechanisms through which BYF alleviates COPD remains unclear. Cellular senescence is crucial in the pathogenesis… read more here.
Keywords: senescence; foxo3a pathway; sirt1 foxo3a; ampk sirt1 ... See more keywords
AMPK/Sirt1-mediated inflammation is positively correlated with myocardial fibrosis during ageing
Sign Up to like & getrecommendations! Published in 2022 at "Acta Cardiologica"
DOI: 10.1080/00015385.2022.2119667
Abstract: Abstract Objectives Cardiovascular disease is the leading cause of death in the world, and it increases dramatically with ageing. The objective of this study was to elucidate age-dependent molecular changes of inflammation and its correlation… read more here.
Keywords: inflammation; positively correlated; myocardial fibrosis; ampk sirt1 ... See more keywords
The AMPK-SIRT1-FoxO1-NF-κB signaling pathway participates in hesperetin-mediated neuroprotective effects against traumatic brain injury via the NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2096464
Abstract: Abstract Background Traumatic brain injury (TBI) induces inflammations that lead to secondary damage. Hesperetin (Hes) exerts anti-inflammatory activities against central nervous system (CNS) diseases. This article probes the possible neuroprotective effect and mechanism of Hes… read more here.
Keywords: sirt1 foxo1; ampk sirt1; brain;
lncRNA NBR2 attenuates angiotensin II-induced myocardial hypertrophy through repressing ER stress via activating LKB1/AMPK/Sirt1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2062527
Abstract: ABSTRACT Myocardial hypertrophy leads to heart failure (HF), and emerging researchers have illustrated that long noncoding RNAs (lncRNAs) modulate myocardial hypertrophy. Here, we explored the role and mechanism of a novel lncRNA, NBR2, in modulating… read more here.
Keywords: myocardial hypertrophy; hypertrophy; ampk sirt1; lncrna nbr2 ... See more keywords
rhCC16 Suppresses Cellular Senescence and Ameliorates COPD‐Like Symptoms by Activating the AMPK/Sirt1‐PGC‐1‐α‐TFAM Pathway to Promote Mitochondrial Function
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70566
Abstract: Chronic obstructive pulmonary disease (COPD) is a widespread lung disease marked by alveolar wall damage, leading to inflammation and fibrosis. Key risk factors include age, smoking, sex, and education, with smoking being the most crucial.… read more here.
Keywords: senescence; cellular senescence; ampk sirt1; function ... See more keywords