Evaluation of Programmed Death Ligand 1 (PD-L1) Gene Amplification and Response to Nivolumab Monotherapy in Non-small Cell Lung Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2020.11818
Abstract: Importance Robust predictors for response to anti-programmed death 1 and its ligand (PD-1/PD-L1) immunotherapy in non-small cell lung cancer (NSCLC) are not fully characterized. Objective To evaluate whether PD-L1 (CD274) copy number gains (CNGs), comprising… read more here.
Keywords: nivolumab monotherapy; response; response nivolumab; programmed death ... See more keywords
High Sensitivity Graphene Field Effect Transistor‐Based Detection of DNA Amplification
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202001031
Abstract: Enzymatic DNA amplification-based approaches involving intercalating DNA-binding fluorescent dyes and expensive optical detectors are the gold standard for nucleic acid detection. As components of a simplified and miniaturized system, conventional silicon-based ion sensitive field effect… read more here.
Keywords: detection; dna; dna amplification; field effect ... See more keywords
A Bioinspired Nanoprobe with Multilevel Responsive T1 -Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201906799
Abstract: Metastasis remains the major cause of death in cancer patients. Thus, there is a need to sensitively detect tumor metastasis, especially ultrasmall metastasis, for early diagnosis and precise treatment of cancer. Herein, an ultrasensitive T1… read more here.
Keywords: creka; bioinspired nanoprobe; umfnp creka; metastasis ... See more keywords
Ultrasound-Triggered Cascade Amplification of Nanotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303158
Abstract: Ultrasound (US)-triggered cascade amplification of nanotherapies has attracted considerable attention as an effective strategy for cancer treatment. With the remarkable advances in materials chemistry and nanotechnology, a large number of well-designed nanosystems have emerged that… read more here.
Keywords: amplification nanotherapy; triggered cascade; amplification; ultrasound triggered ... See more keywords
Deep‐dLAMP: Deep Learning‐Enabled Polydisperse Emulsion‐Based Digital Loop‐Mediated Isothermal Amplification
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105450
Abstract: Abstract Digital nucleic acid amplification tests enable absolute quantification of nucleic acids, but the generation of uniform compartments and reading of the fluorescence requires specialized instruments that are costly, limiting their widespread applications. Here, the… read more here.
Keywords: dlamp; amplification; deep dlamp; deep learning ... See more keywords
Immobilization-Free Electrochemical DNA Sensor based on signal cascade amplification strategy.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2174
Abstract: The development of convenient and efficient strategies without using complex nanomaterials or enzymes for signal amplification is very important for bioanalytical applications. Herein, a novel electrochemical DNA sensor was developed by harnessing the signal amplification… read more here.
Keywords: target dna; dna; electrochemical dna; dna sensor ... See more keywords
MYCN amplification plus 1p36 loss of heterozygosity predicts ultra high risk in bone marrow metastatic neuroblastoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.4583
Abstract: BACKGROUND This study aimed to better understand the prognostic effect of multiple genetic markers and identify more subpopulations at ultra high risk of poor outcome in bone marrow (BM) metastatic neuroblastoma (NB). METHODS We screened… read more here.
Keywords: ultra high; amplification; mycn amplification; high risk ... See more keywords
Allosteric Probe Recognition Initiated Cascade Transcription Amplification for Sensitive Analysis of Exosomes
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200067
Abstract: Sensitive and accurate analysis of exosomes is important for many biological processes including as a biomarker for cerebral venous thrombosis (CVT) diagnosis and therapy. Herein, we established a sensitive and specific exosome detection approach based… read more here.
Keywords: recognition; recognition initiated; analysis exosomes; amplification ... See more keywords
Catalysts Supported by Homochiral Molecular Helices: A New Concept to Implement Asymmetric Amplification in Catalytic Science
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201901246
Abstract: Connecting intrinsically achiral catalytic centers to helical polymers provides a new class of asymmetric catalysts whose selectivity exclusively stems from the chiral environment provided by the helical polymer. Chirality amplification phenomena allow to control the… read more here.
Keywords: molecular helices; homochiral molecular; helices new; supported homochiral ... See more keywords
Optimization and application of loop‐mediated isothermal amplification technique for sex identification in red‐whiskered bulbul (Pycnonotus jocosus)
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1002/ece3.9401
Abstract: Abstract The red‐whiskered bulbul (Pycnonotus jocosus) is a popular avian species in Thailand and many other countries. The red‐whiskered bulbul has a high economic value, but breeding is challenging since sex identification is difficult. The… read more here.
Keywords: whiskered bulbul; sex identification; red whiskered; amplification ... See more keywords
ERG amplification is a secondary recurrent driver event in myeloid malignancy with complex karyotype and TP53 mutations
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23027
Abstract: ERG is a transcription factor encoded on chromosome 21q22.2 with important roles in hematopoiesis and oncogenesis of prostate cancer. ERG amplification has been identified as one of the most common recurrent events in acute myeloid… read more here.
Keywords: complex karyotype; amplification; driver event; erg amplification ... See more keywords