USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
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DOI: 10.26508/lsa.202000768
Abstract: A new inhibitor of the deubiquitylase USP30, an actionable target relevant to Parkinson’s Disease, is introduced and characterised for parameters related to mitophagy. The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria.… read more here.
Keywords: mitochondrial ubiquitylation; usp30 sets; ubiquitylation; amplification mitochondrial ... See more keywords