Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
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DOI: 10.1038/s41416-018-0315-3
Abstract: BackgroundInterferon-induced expression of programmed cell death ligands (PD-L1/PD-L2) may sustain tumour immune-evasion. Patients featuring MET amplification, a genetic lesion driving transformation, may benefit from anti-MET treatment. We explored if MET-targeted therapy interferes with Interferon-γ modulation… read more here.
Keywords: treatment; interferon; amplified tumours; induction ligands ... See more keywords