Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Drug Delivery Reviews"
DOI: 10.1016/j.addr.2021.113900
Abstract: The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA (saRNA) as a flexible immunotherapy platform to treat infectious diseases. Besides the… read more here.
Keywords: amplifying mrna; self amplifying; innate immune; activity ... See more keywords
Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.11.040
Abstract: Nucleic acid vaccines represent an attractive approach to vaccination, combining the positive attributes of both viral vectors and live-attenuated vaccines, without the inherent limitations of each technology. We have developed a novel technology, the Self-Amplifying… read more here.
Keywords: sam vaccines; amplifying mrna; bacterial antigens; immunogenicity ... See more keywords