Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.04.026
Abstract: During disease, cells experience various stresses that manifest as an accumulation of misfolded proteins and eventually lead to cell death. To combat this stress, cells activate a pathway called unfolded protein response that functions to… read more here.
Keywords: disease; ampylation; parkinson disease; alpha synuclein ... See more keywords
Revisiting AMPylation through the lens of Fic enzymes.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in microbiology"
DOI: 10.1016/j.tim.2021.08.003
Abstract: AMPylation, a post-translational modification (PTM) first discovered in the late 1960s, is catalyzed by adenosine monophosphate (AMP)-transferring enzymes. The observation that filamentation-induced-by-cyclic-AMP (fic) enzymes are associated with this unique PTM revealed that AMPylation plays a… read more here.
Keywords: fic enzymes; ampylation; lens fic; revisiting ampylation ... See more keywords
Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22596-0
Abstract: To adapt to fluctuating protein folding loads in the endoplasmic reticulum (ER), the Hsp70 chaperone BiP is reversibly modified with adenosine monophosphate (AMP) by the ER-resident Fic-enzyme FICD/HYPE. The structural basis for BiP binding and… read more here.
Keywords: tpr motifs; chaperone bip; motifs ficd; ampylation ... See more keywords
Fic and non-Fic AMPylases: protein AMPylation in metazoans
Sign Up to like & getrecommendations! Published in 2021 at "Open Biology"
DOI: 10.1098/rsob.210009
Abstract: Protein AMPylation refers to the covalent attachment of an AMP moiety to the amino acid side chains of target proteins using ATP as nucleotide donor. This process is catalysed by dedicated AMP transferases, called AMPylases.… read more here.
Keywords: protein ampylation; ampylases protein; fic non; ampylation ... See more keywords
AMPylation and Endoplasmic Reticulum Protein Folding Homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041265
Abstract: The endoplasmic reticulum (ER)-localized Hsp70 chaperone, BiP, undergoes a rapid, reversible and inactivating post-translational modification. This covalent modification complements the slower, conventional unfolded protein response (UPR) in matching the supply of active Hsp70 chaperone to… read more here.
Keywords: endoplasmic reticulum; protein folding; bip; ampylation ... See more keywords
Infancy‐onset diabetes caused by de‐regulated AMPylation of the human endoplasmic reticulum chaperone BiP
Sign Up to like & getrecommendations! Published in 2023 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202216491
Abstract: Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset diabetes mellitus and severe neurodevelopmental… read more here.
Keywords: endoplasmic reticulum; onset diabetes; infancy onset; bip ... See more keywords
Catalytic deAMPylation in AMPylation-inhibitory/assistant forms of FICD protein
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1077188
Abstract: DeAMPylation, as a reversible reaction of AMPylation and mediated by the endoplasmic reticulum-localized enzyme FICD (filamentation induced by cAMP domain protein, also known as HYPE), is an important process in protein posttranslational modifications (PTMs). Elucidating… read more here.
Keywords: deampylation; assistant forms; ampylation; inhibitory assistant ... See more keywords