The role of BDNF methylation and Val66Met in amygdala reactivity during emotion processing
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DOI: 10.1002/hbm.24825
Abstract: Epigenetic alterations of the brain‐derived neurotrophic factor (BDNF) gene have been associated with psychiatric disorders in humans and with differences in amygdala BDNF mRNA levels in rodents. This human study aimed to investigate the relationship… read more here.
Keywords: methylation; amygdala reactivity; bdnf methylation; bdnf ... See more keywords
A Common Polymorphism in a Williams Syndrome Gene Predicts Amygdala Reactivity and Extraversion in Healthy Adults
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DOI: 10.1016/j.biopsych.2015.12.007
Abstract: BACKGROUND Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within… read more here.
Keywords: amygdala reactivity; threat related; reactivity; williams syndrome ... See more keywords
Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity
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DOI: 10.1016/j.biopsych.2017.11.010
Abstract: BACKGROUND Low replication rates are a concern in most, if not all, scientific disciplines. In psychiatric genetics specifically, targeting intermediate brain phenotypes, which are more closely associated with putative genetic effects, was touted as a… read more here.
Keywords: amygdala reactivity; genetics; threat related; replication ... See more keywords
Probing the association between serotonin-1A autoreceptor binding and amygdala reactivity in healthy volunteers
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DOI: 10.1016/j.neuroimage.2017.12.092
Abstract: Introduction: The serotonergic system modulates affect and is a target in the treatment of mood disorders. 5‐HT1A autoreceptors in the raphe control serotonin release by means of negative feedback inhibition. Hence, 5‐HT1A autoreceptor function should… read more here.
Keywords: amygdala reactivity; reactivity; binding amygdala; ht1a autoreceptor ... See more keywords
Impact of short- and long-term mindfulness meditation training on amygdala reactivity to emotional stimuli
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DOI: 10.1016/j.neuroimage.2018.07.013
Abstract: ABSTRACT Meditation training can improve mood and emotion regulation, yet the neural mechanisms of these affective changes have yet to be fully elucidated. We evaluated the impact of long‐ and short‐term mindfulness meditation training on… read more here.
Keywords: meditation training; amygdala reactivity; term; training ... See more keywords
Biological profiling of prospective antidepressant response in major depressive disorder: Associations with (neuro)inflammation, fatty acid metabolism, and amygdala-reactivity
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DOI: 10.1016/j.psyneuen.2017.02.019
Abstract: BACKGROUND A better understanding of factors underlying antidepressant non-response may improve the prediction of which patients will respond to what treatment. Major depressive disorder (MDD) is associated with alterations in fatty acid metabolism, (neuro)inflammation and… read more here.
Keywords: neuro inflammation; amygdala reactivity; response; antidepressant response ... See more keywords
Paradoxical associations between familial affective responsiveness, stress, and amygdala reactivity.
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DOI: 10.1037/emo0000467
Abstract: Studies of early life extremes such as trauma, abuse, and neglect highlight the critical importance of quality caregiving in the development of brain circuits supporting emotional behavior and mental health. The impact of normative variability… read more here.
Keywords: amygdala reactivity; paradoxical associations; affective responsiveness; reactivity ... See more keywords
An earlier time of scan is associated with greater threat-related amygdala reactivity
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DOI: 10.1093/scan/nsx057
Abstract: Abstract Time-dependent variability in mood and anxiety suggest that related neural phenotypes, such as threat-related amygdala reactivity, may also follow a diurnal pattern. Here, using data from 1,043 young adult volunteers, we found that threat-related… read more here.
Keywords: related amygdala; amygdala reactivity; time; threat related ... See more keywords