Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants
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DOI: 10.1002/ardp.202200400
Abstract: Herein, a library of novel pyridone derivatives 1–34 was designed, synthesized, and evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1–34 were synthesized via a one‐pot multi‐component reaction of variously… read more here.
Keywords: bioevaluation synthetic; glucosidase; pyridones dual; amylase glucosidase ... See more keywords
α-Amylase and α-glucosidase inhibitory activities of the herbs of Artemisia dracunculus L. and its active constituents
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DOI: 10.1007/s00044-017-2014-7
Abstract: A new phenylpropanoid named 4-(1′,1′,2′,2′-tetramethylpropyl)-1,2-benzenediol (1) with a known phenylpropanoid: 3-(p-methoxyphenyl)-1,2-propanediol (2), a coumarin: herniarin (3), and a flavonol glycoside: rutin (4) were isolated from the aerial parts of Artemisia dracunculus L. Their structures were… read more here.
Keywords: activities herbs; inhibitory activities; artemisia dracunculus; inhibitory ... See more keywords
Phenolic content, antioxidant capacity, and α-amylase and α-glucosidase inhibitory activities of Dimocarpus longan Lour.
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DOI: 10.1007/s10068-019-00708-3
Abstract: The aim of this study was to compare the phenolic compound profiles and antioxidant capacities of eight varieties of longan (Dimocarpus longan Lour.) planted in the middle and upper Yangtze River area. The total polyphenols… read more here.
Keywords: dimocarpus longan; phenolic content; content; amylase glucosidase ... See more keywords
Synthesis, characterization, and hypoglycemic efficacy of nitro and amino acridines and 4-phenylquinoline on starch hydrolyzing compounds: an in silico and in vitro study
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DOI: 10.1007/s11224-020-01529-5
Abstract: α-Amylase and α-Glucosidase are important therapeutic targets for type II diabetes. The present focus of our study is to elucidate the hypoglycemic activity of novel compounds through in vitro and in silico studies. Here, we… read more here.
Keywords: amino acridines; starch hydrolyzing; amylase glucosidase; study ... See more keywords
α-Amylase and α-glucosidase inhibitor effects and pancreatic response to diabetes mellitus on Wistar rats of Ephedra alata areal part decoction with immunohistochemical analyses
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DOI: 10.1007/s11356-019-04339-3
Abstract: Ephedra alata, known as a medicinal plant in China, was used in this study as aqueous extract from aerial parts, for diabetes mellitus treatment. This study was carried out on two parts, in vitro, we… read more here.
Keywords: inhibitor effects; ephedra alata; diabetes mellitus; glucosidase inhibitor ... See more keywords
Evaluation of invitro α-amylase and α-glucosidase inhibitory potential of N2O2 schiff base Zn complex
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DOI: 10.1016/j.arabjc.2014.07.002
Abstract: Abstract The evaluation of the antioxidant, antibacterial and enzyme inhibition effects of N 2 O 2 Schiff base Zn complex was investigated. The percentage scavenging activity of hydroxyl radical (IC 50 -0.21 μg), ABTS (IC 50… read more here.
Keywords: complex; base complex; amylase glucosidase; znl complex ... See more keywords
Dipyridamole inhibits α-amylase/α-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102972
Abstract: Dipyridamole (DP) elevates cyclic Adenosine Monophosphate (cAMP) levels in platelets, erythrocytes, and endothelial cells and also blocks adenosine reuptake. It is used to dilate blood vessels in people with peripheral arterial disease and coronary artery… read more here.
Keywords: inhibits amylase; glucosidase sub; glu amy; dipyridamole inhibits ... See more keywords
The inhibitory mechanism of chlorogenic acid and its acylated derivatives on α-amylase and α-glucosidase.
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DOI: 10.1016/j.foodchem.2021.131334
Abstract: Due to the poor lipophilicity of chlorogenic acid (CA), five CA derivatives (C2-CA, C4-CA, C6-CA, C8-CA, and C12-CA) with different lipophilicities were synthesized using acylation catalyzed by lipase in present study. The inhibitory activities and… read more here.
Keywords: inhibitory; chlorogenic acid; derivatives amylase; glucosidase ... See more keywords
Malaysian brown seaweeds Sargassum siliquosum and Sargassum polycystum: Low density lipoprotein (LDL) oxidation, angiotensin converting enzyme (ACE), α-amylase, and α-glucosidase inhibition activities.
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DOI: 10.1016/j.foodres.2017.01.023
Abstract: Two Malaysian brown seaweeds, Sargassum siliquosum and Sargassum polycystum were first extracted using methanol to get the crude extract (CE) and further fractionated to obtain fucoxanthin-rich fraction (FRF). Samples were evaluated for their phenolic, flavonoid,… read more here.
Keywords: oxidation; ace amylase; ldl oxidation; amylase glucosidase ... See more keywords
Clitoria ternatea L. petal bioactive compounds display antioxidant, antihemolytic and antihypertensive effects, inhibit α-amylase and α-glucosidase activities and reduce human LDL cholesterol and DNA induced oxidation.
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DOI: 10.1016/j.foodres.2019.108763
Abstract: The purpose of this study was to use a statistical approach to optimise the experimental conditions regarding the extraction of bioactive compounds, and to analyse the in vitro functional properties of crude lyophilized extracts (CLE)… read more here.
Keywords: bioactive compounds; amylase glucosidase; clitoria ternatea; ldl cholesterol ... See more keywords
The enhanced inhibition of water extract of black tea under baking treatment on α-amylase and α-glucosidase.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.08.152
Abstract: This paper studied the inhibition of water extract of natural or baked black tea on the activity of α-amylase and α- glucosidase. Baking treatment was found to be one effective way to enhance the inhibition… read more here.
Keywords: water extract; amylase; tea; black tea ... See more keywords