Common bean (Phaseolus vulgaris L.) α‐amylase inhibitors as safe nutraceutical strategy against diabetes and obesity: An update review
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7480
Abstract: Overweight and obesity are constantly increasing, not only in Western countries but also in low‐middle‐income ones. The decrease of both the intake of carbohydrates and their assimilation are among the main dietary strategies to counter… read more here.
Keywords: bean phaseolus; amylase inhibitors; common bean; phaseolus vulgaris ... See more keywords
Online screening of α-amylase inhibitors by capillary electrophoresis
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-1073-z
Abstract: AbstractPancreatic α-amylase plays an important role in dietary starch hydrolysis in the small intestine and participates in enhanced glucose concentration after meals. It seems to be a problem for diabetic patients, who suffer from longer… read more here.
Keywords: capillary electrophoresis; amylase inhibitors; effect; screening amylase ... See more keywords
In silico docking studies of α-amylase inhibitors from the anti-diabetic plant Leucas ciliata Benth. and an endophyte, Streptomyces longisporoflavus
Sign Up to like & getrecommendations! Published in 2021 at "3 Biotech"
DOI: 10.1007/s13205-020-02547-0
Abstract: In this investigation, potential inhibitors of α-amylase, one of the key regulatory enzymes in diabetes were characterized from the methanolic extract of Leucas ciliata Benth. (Lamiaceae), a traditional medicinal plant of the Western Ghats, southern… read more here.
Keywords: leucas ciliata; amylase inhibitors; plant; docking studies ... See more keywords
Synthesis of alpha amylase inhibitors based on privileged indole scaffold.
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DOI: 10.1016/j.bioorg.2017.04.010
Abstract: Twenty five derivatives of indole carbohydrazide (1-25) had been synthesized. These compounds were characterized using 1H NMR and EI-MS, and further evaluated for their α-amylase inhibitory potential. The analogs (1-25) showed varying degree of α-amylase… read more here.
Keywords: inhibitory potential; amylase inhibitors; alpha amylase; amylase ... See more keywords
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104507
Abstract: In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3'-oxindoles]. They were obtained by one-pot… read more here.
Keywords: rhodanine; novel amylase; amylase inhibitors; study ... See more keywords
Screening and identifying of α-amylase inhibitors from medicine food homology plants: Insights from computational analysis and experimental studies.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13536
Abstract: There is a growing interest in screening α-amylase inhibitors from natural products for application in the development of new antidiabetic drugs or functional foods. In this study, a structure-based virtual screening was applied to rapidly… read more here.
Keywords: medicine; amylase inhibitors; food homology; amylase ... See more keywords
Acetylcholinesterase and α-Amylase inhibitors from Mouriri elliptica Martius leaf extract
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Journal"
DOI: 10.14393/bj-v36n2a2020-42714
Abstract: Population growth has raised food production, and new sources are needed to increase quantity and quality of agricultural products. Carbamates and organophosphates are insecticide classes used worldwide as acetylcholinesterase (AChE) inhibitors. Plants have a natural… read more here.
Keywords: amylase inhibitors; elliptica martius; mouriri elliptica; acetylcholinesterase amylase ... See more keywords