Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.08.003
Abstract: α-Amylase is a target for type-2 diabetes mellitus treatment. However, small molecule inhibitors of α-amylase are currently scarce. In the course of developing small molecule α-amylase inhibitors, we designed and synthesized thiadiazole quinoline analogs (1-30),… read more here.
Keywords: thiadiazole quinoline; amylase inhibitory; inhibitory potential; amylase ... See more keywords
Synthesis, α-amylase inhibitory potential and molecular docking study of indole derivatives.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.05.021
Abstract: In search of potent α-amylase inhibitor we have synthesized eighteen indole analogs (1-18), characterized by NMR and HR-EIMS and screened for α-amylase inhibitory activity. All analogs exhibited a variable degree of α-amylase inhibition with IC50… read more here.
Keywords: synthesis amylase; docking study; molecular docking; amylase inhibitory ... See more keywords
New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103284
Abstract: New triazinoindole bearing thiazole/oxazole analogues (1-21) were synthesized and characterized through spectroscopic techniques such as HREI-MS, 1H and 13C NMR. The configuration of compound 2i and 2k was confirmed through NOESY. All analogues were evaluated… read more here.
Keywords: inhibitory potential; thiazole oxazole; amylase inhibitory; new triazinoindole ... See more keywords
2-Aryl benzimidazoles: Synthesis, In vitro α-amylase inhibitory activity, and molecular docking study.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.011
Abstract: Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely explored for the α-amylase inhibitory activity. For that purpose, 2-aryl benzimidazole derivatives 1-45 were synthesized and screened for in vitro α-amylase inhibitory activity.… read more here.
Keywords: vitro amylase; inhibitory activity; inhibitory; amylase inhibitory ... See more keywords
Silychristin derivatives conjugated with coniferylalcohols from silymarin and their pancreatic α-amylase inhibitory activity
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1499639
Abstract: Abstract Silymarin is a mixture of flavonolignans extracted from the fruit of Silybum marianum (milk thistle). The latter is used as a medicinal plant to treat liver and gallbladder disorders. Recently, silymarin has been investigated… read more here.
Keywords: inhibitory activity; silychristin derivatives; amylase inhibitory;
α-Glucosidase inhibitory and α-amylase inhibitory activities of compounds isolated from Uvaria rufa Blume.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2041010
Abstract: A new C-benzylated flavone, uvariaruflavone (1), along with 13 known compounds (2-14) were isolated from the twig and leaf extracts of Uvaria rufa Blume. Their structures were established by extensive spectroscopic methods. Flavones (5-8) and… read more here.
Keywords: rufa blume; inhibitory; uvaria rufa; inhibitory activities ... See more keywords
Analysis of Phenolic and Flavonoid Content, α-Amylase Inhibitory and Free Radical Scavenging Activities of Some Medicinal Plants
Sign Up to like & getrecommendations! Published in 2022 at "The Scientific World Journal"
DOI: 10.1155/2022/4000707
Abstract: In Nepal, about 700 plant species have been reported to be used for the primary care of different diseases. However, many of them have not been studied yet for their scientific evidence. The main aim… read more here.
Keywords: amylase inhibitory; radical scavenging; free radical; activity ... See more keywords
Antioxidant, α-Glucosidases and α-Amylase Inhibitory Activities of Persicaria odorata
Sign Up to like & getrecommendations! Published in 2021 at "Chiang Mai University Journal of Natural Sciences"
DOI: 10.12982/cmujns.2021.051
Abstract: The objects of this study were to determine the effects to reactive oxygen species and antioxidant enzymes levels in HEK-293 cells and inhibition of α-glucosidases and α-amylase enzymes of extracts from Persicaria odorata or phak… read more here.
Keywords: persicaria odorata; amylase inhibitory; phak phaeo; antioxidant glucosidases ... See more keywords
New Alpha-Amylase Inhibitory Metabolites from Pericarps of Garcinia mangostana
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12030384
Abstract: Two new benzophenones: garcimangophenones A (6) and B (7) and five formerly reported metabolites were purified from the pericarps EtOAc fraction of Garcinia mangostana ((GM) Clusiaceae). Their structures were characterized by various spectral techniques and… read more here.
Keywords: amylase; new alpha; amylase inhibitory; garcinia mangostana ... See more keywords