Effects of sub-chronic amylin receptor activation on alcohol-induced locomotor stimulation and monoamine levels in mice
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05607-8
Abstract: Amylin receptors consist of the calcitonin receptor (CTR) and one of three receptor activity-modifying proteins (RAMPs). The identification of amylin receptors in areas processing reward, namely laterodorsal tegmental area (LDTg), ventral tegmental area (VTA), and… read more here.
Keywords: sub chronic; treatment; alcohol induced; receptor ... See more keywords
Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.11.006
Abstract: Hyperamylinemia is a condition that accompanies obesity and precedes type II diabetes, and it is characterized by above-normal blood levels of amylin, the pancreas-derived peptide. Human amylin oligomerizes easily and can deposit in the pancreas… read more here.
Keywords: calcium dysregulation; amylin induced; human amylin; ca2 ... See more keywords
Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28131-z
Abstract: Social animals actively engage in contact with conspecifics and experience stress upon isolation. However, the neural mechanisms coordinating the sensing and seeking of social contacts are unclear. Here we report that amylin-calcitonin receptor (Calcr) signaling… read more here.
Keywords: amylin calcitonin; calcitonin receptor; amylin; preoptic area ... See more keywords
Mechanistic perspective and functional activity of insulin in amylin aggregation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00481a
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c8sc00481a
Abstract: This work provides the first-ever complete atomic model of insulin–amylin aggregates, identifying the specific interactions that stabilize the insulin–amylin complex. read more here.
Keywords: mechanistic perspective; perspective functional; functional activity; insulin amylin ... See more keywords
Physico-chemical stability of co-formulation of PEGylated human amylin with insulin
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2019.1621896
Abstract: Abstract Since the discovery of amylin no combined formulation with insulin has been made available. Amylin or its triple proline analog pramlintide are not compatible in solution with insulin. The drug candidate hAmy-PEG5k is a… read more here.
Keywords: insulin; hamy peg5k; glargine detemir; human amylin ... See more keywords
A structural basis for amylin receptor phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abm9609
Abstract: Amylin receptors (AMYRs) are heterodimers of the calcitonin (CT) receptor (CTR) and one of three receptor activity–modifying proteins (RAMPs), AMY1R, AMY2R, and AMY3R. Selective AMYR agonists and dual AMYR/CTR agonists are being developed as obesity… read more here.
Keywords: ramy; amy2r; amylin; sct ... See more keywords
Amylin receptor agonism protects against metabolic side effects of acute olanzapine
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730313
Abstract: Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of schizophrenia and several on- and off-label conditions. While effective in reducing psychoses, acute olanzapine treatment causes rapid hyperglycemia, insulin resistance, and dyslipidemia and these… read more here.
Keywords: acute olanzapine; physiology; olanzapine induced; amylin ... See more keywords
Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-017-0972-9
Abstract: BackgroundNeuroinflammation in the brain consequent to activation of microglia is viewed as an important component of Alzheimer’s disease (AD) pathology. Amyloid beta (Aβ) protein is known to activate microglia and unleash an inflammatory cascade that… read more here.
Keywords: amyloid; amylin receptor; amylin receptors; beta ... See more keywords
The Importance of Understanding Amylin Signaling Mechanisms for Therapeutic Development in the Treatment of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical design"
DOI: 10.2174/1381612826666200318151146
Abstract: Type II Diabetes (T2D) is a major risk factor for Alzheimer's Disease (AD). These two diseases share several pathological features including amyloid accumulation, inflammation, oxidative stress, cell death and cognitive decline. The metabolic hormone amylin… read more here.
Keywords: alzheimer disease; amyloid beta; importance understanding; amylin ... See more keywords
Bloodborne Pancreatic Amylin, A Therapeutic Target for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Current Alzheimer research"
DOI: 10.2174/1567205020666230217091540
Abstract: Alzheimer Disease (AD) pathology has been linked to brain accumulation of β amyloid (Aβ) and neurofibrillary tau tangles. An intriguing question is whether targeting therapeutically factors independent of Aβ and tau pathologies could delay or… read more here.
Keywords: alzheimer disease; bloodborne pancreatic; pathology; amylin ... See more keywords
Brain Distribution and Sexually Dimorphic Expression of Amylin in Different Reproductive Stages of the Zebra Finch (Taeniopygia guttata) Suggest Roles of the Neuropeptide in Song Learning and Social Behaviour
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.01401
Abstract: The expression of the recently identified neuropeptide, amylin, is restricted in rodents to the postpartum preoptic area and may play a role in the control of parental behaviours and food intake. These processes are substantially… read more here.
Keywords: different reproductive; zebra finch; sexually dimorphic; brain ... See more keywords