Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2019.4421
Abstract: Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for Alzheimer disease. While APOEε4 is associated with increased amyloid-β burden, its association with cerebral tau pathology has been controversial. Objective To… read more here.
Keywords: pet; tau; amyloid; alzheimer disease ... See more keywords
Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2024.2579
Abstract: Importance Anti-β-amyloid immunotherapy using lecanemab is becoming increasingly available to patients with Alzheimer disease (AD). Individuals with Down syndrome (DS) develop AD neuropathology by age 40 years, representing a significant cohort of genetically determined AD.… read more here.
Keywords: brain; lecanemab vascular; amyloid; brains people ... See more keywords
PDB_Amyloid: an extended live amyloid structure list from the PDB
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12524
Abstract: The Protein Data Bank (PDB) contains more than 135 000 entries at present. From these, relatively few amyloid structures can be identified, since amyloids are insoluble in water. Therefore, most amyloid structures deposited in the… read more here.
Keywords: amyloid; pdb amyloid; amyloid structures; pdb ... See more keywords
Silica Nanodepletors: Targeting and Clearing Alzheimer's β‐Amyloid Plaques
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201910475
Abstract: Abnormal accumulation of β‐amyloid (Aβ) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). Aβ aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been… read more here.
Keywords: amyloid; silica nanodepletors; clearing alzheimer; targeting clearing ... See more keywords
Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque-rich Cortex.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202515674
Abstract: A hallmark of Alzheimer's disease (AD) is the accumulation of amyloid plaques, primarily composed of misfolded amyloid β (Aβ) peptides. Complementary high‐resolution imaging techniques are employed to investigate the plaque penetrability and the extracellular space… read more here.
Keywords: amyloid plaque; extracellular space; amyloid; cortex ... See more keywords
Decreased Cerebrospinal Fluid Amyloid β 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Neurology"
DOI: 10.1002/ana.26610
Abstract: Vascular amyloid β (Aβ) accumulation is the hallmark of cerebral amyloid angiopathy (CAA). The composition of cerebrospinal fluid (CSF) of CAA patients may serve as a diagnostic biomarker of CAA. We studied the diagnostic potential… read more here.
Keywords: amyloid angiopathy; caa; cerebrospinal fluid; amyloid ... See more keywords
Protective effect of extractive and biotechnological chondroitin in insulin amyloid and advanced glycation end product‐induced toxicity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27153
Abstract: Glycosaminoglycans are extracellular matrix components related to several biological functions and diseases. Chondroitin sulfate is a sulphated glycosaminoglycan synthesized as part of proteoglycan molecules. They are frequently associated with amyloid deposits and possess an active… read more here.
Keywords: amyloid; chondroitin; end; toxicity ... See more keywords
Identification of binding partners that facilitate membrane‐type 5 matrix metalloproteinase (MT5‐MMP) processing of amyloid precursor protein
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31218
Abstract: One of the pathological hallmarks of Alzheimer's disease (AD) is the presence of extracellular deposits of amyloid beta (Aβ) peptide. In addition to Aβ as the core component of the amyloid plaque, the amyloid precursor… read more here.
Keywords: mmp; mt5 mmp; amyloid; protein ... See more keywords
Paired PET‐MRI Deep Learning Model for Translating [11C]PiB to [18F]Florbetaben Amyloid Images
Sign Up to like & getrecommendations! Published in 2025 at "Medical Physics"
DOI: 10.1002/mp.70168
Abstract: Amyloid PET imaging has been extensively employed in the noninvasive assessment of amyloid‐beta accumulation in Alzheimer's disease. Various amyloid radiotracers are commonly used in clinical settings; however, the limited interchangeability among these radiotracers hinders the… read more here.
Keywords: deep learning; mri deep; pet mri; paired pet ... See more keywords
Amyloidogenesis of Tau protein
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3275
Abstract: The role of microtubule‐associated protein Tau in neurodegeneration has been extensively investigated since the discovery of Tau amyloid aggregates in the brains of patients with Alzheimer's disease (AD). The process of formation of amyloid fibrils… read more here.
Keywords: protein; tau; amyloid; prion ... See more keywords
Yes we can analyse amyloid images - Now What?
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-017-3644-1
Abstract: With the recent introduction of amyloid PET tracers into clinical use, non-invasive biomarker information on brain amyloidosis is available which challenges the long-accepted gold standard of post mortem histopathology for diagnosing Alzheimer’s disease (AD). Phase… read more here.
Keywords: brain amyloid; amyloid; amyloid pet; pathology ... See more keywords