Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2019.4421
Abstract: Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for Alzheimer disease. While APOEε4 is associated with increased amyloid-β burden, its association with cerebral tau pathology has been controversial. Objective To… read more here.
Keywords: pet; tau; amyloid; alzheimer disease ... See more keywords
PDB_Amyloid: an extended live amyloid structure list from the PDB
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12524
Abstract: The Protein Data Bank (PDB) contains more than 135 000 entries at present. From these, relatively few amyloid structures can be identified, since amyloids are insoluble in water. Therefore, most amyloid structures deposited in the… read more here.
Keywords: amyloid; pdb amyloid; amyloid structures; pdb ... See more keywords
Silica Nanodepletors: Targeting and Clearing Alzheimer's β‐Amyloid Plaques
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201910475
Abstract: Abnormal accumulation of β‐amyloid (Aβ) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). Aβ aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been… read more here.
Keywords: amyloid; silica nanodepletors; clearing alzheimer; targeting clearing ... See more keywords
Decreased Cerebrospinal Fluid Amyloid β 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Neurology"
DOI: 10.1002/ana.26610
Abstract: Vascular amyloid β (Aβ) accumulation is the hallmark of cerebral amyloid angiopathy (CAA). The composition of cerebrospinal fluid (CSF) of CAA patients may serve as a diagnostic biomarker of CAA. We studied the diagnostic potential… read more here.
Keywords: amyloid angiopathy; caa; cerebrospinal fluid; amyloid ... See more keywords
Protective effect of extractive and biotechnological chondroitin in insulin amyloid and advanced glycation end product‐induced toxicity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27153
Abstract: Glycosaminoglycans are extracellular matrix components related to several biological functions and diseases. Chondroitin sulfate is a sulphated glycosaminoglycan synthesized as part of proteoglycan molecules. They are frequently associated with amyloid deposits and possess an active… read more here.
Keywords: amyloid; chondroitin; end; toxicity ... See more keywords
Amyloidogenesis of Tau protein
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3275
Abstract: The role of microtubule‐associated protein Tau in neurodegeneration has been extensively investigated since the discovery of Tau amyloid aggregates in the brains of patients with Alzheimer's disease (AD). The process of formation of amyloid fibrils… read more here.
Keywords: protein; tau; amyloid; prion ... See more keywords
Yes we can analyse amyloid images - Now What?
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-017-3644-1
Abstract: With the recent introduction of amyloid PET tracers into clinical use, non-invasive biomarker information on brain amyloidosis is available which challenges the long-accepted gold standard of post mortem histopathology for diagnosing Alzheimer’s disease (AD). Phase… read more here.
Keywords: brain amyloid; amyloid; amyloid pet; pathology ... See more keywords
Is there a difference in regional read [18F]flutemetamol amyloid patterns between end-of-life subjects and those with amnestic mild cognitive impairment?
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04282-y
Abstract: PurposeVisual interpretation of PET [18F]flutemetamol images relies on systematic review of five brain regions and is considered positive when an elevated signal is observed in at least one region. Amnestic mild cognitive impairment (aMCI) is… read more here.
Keywords: amnestic mild; amyloid; amci patients; 18f flutemetamol ... See more keywords
Capillary cerebral amyloid angiopathy in Alzheimer’s disease: association with allocortical/hippocampal microinfarcts and cognitive decline
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1834-y
Abstract: Cerebral amyloid angiopathy (CAA) is caused by the deposition of the amyloid β-protein (Aβ) in the wall of cerebral and leptomeningeal blood vessels and is related to Alzheimer’s disease (AD). Capillary Aβ deposition is observed… read more here.
Keywords: amyloid; pathology; caa; capillary caa ... See more keywords
Cerebral amyloid angiopathy: subtypes, treatment and role in cognitive impairment
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurology"
DOI: 10.1007/s00415-017-8608-7
Abstract: Accumulation of β amyloid in leptomeningeal vessels and cortical arterioles is the hallmark of cerebral amyloid angiopathy, this causes vessel stiffening, and vessel wall rupture. Alzheimer’s disease amyloid plaques are composed of β-amyloid 42, whilst… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; amyloid; clearance ... See more keywords
Effect of metal chelators on the aggregation of beta-amyloid peptides in the presence of copper and iron
Sign Up to like & getrecommendations! Published in 2017 at "BioMetals"
DOI: 10.1007/s10534-017-0005-2
Abstract: Amyloid β (Aβ) fibrils and amorphous aggregates are found in the brain of patients with Alzheimer’s disease (AD), and are implicated in the etiology of AD. The metal imbalance is also among leading causes of… read more here.
Keywords: aggregation; amyloid; presence; metal ... See more keywords