Association of Longitudinal β-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.16439
Abstract: Key Points Question What is the trajectory of β-amyloid accumulation over time, and how is it associated with clinical and cognitive decline among patients with probable dementia with Lewy bodies? Findings This cohort study of… read more here.
Keywords: lewy bodies; dementia lewy; accumulation; amyloid accumulation ... See more keywords
Temporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-04773-3
Abstract: Purpose To investigate the temporal trajectories of tau and amyloid-β (Aβ) accumulation in Alzheimer’s disease (AD) by using the longitudinal positron emission tomography (PET) study. Methods A total of 132 participants, who were healthy volunteers… read more here.
Keywords: accumulation; accumulation alzheimer; alzheimer disease; tau amyloid ... See more keywords
Changes in brain amyloid-β accumulation after donepezil administration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2017.08.025
Abstract: Recent studies using the mouse model of Alzheimer's disease (AD) have shown that donepezil administration reduces brain amyloid-β (Aβ) accumulation. This study investigated whether donepezil administration can reduce brain Aβ accumulation in human patients with… read more here.
Keywords: accumulation; amyloid accumulation; donepezil administration; brain amyloid ... See more keywords
Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.05.019
Abstract: Adults with Down syndrome (DS) have a high incidence of Alzheimer's disease (AD), providing a unique opportunity to explore the early, preclinical stages of AD neuropathology. We examined change in brain amyloid-β accumulation via the… read more here.
Keywords: accumulation; consistently pib; amyloid accumulation; brain amyloid ... See more keywords
Associations between brain amyloid accumulation and the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.12.011
Abstract: Some studies suggest that angiotensin II type 1 receptor blockers (ARBs) may protect against memory decline more than angiotensin-converting enzyme inhibitors (ACE-Is), but few have examined possible mechanisms. We assessed longitudinal differences between ARB versus… read more here.
Keywords: accumulation; receptor blockers; use; angiotensin converting ... See more keywords
Rates of β-amyloid deposition indicate widespread simultaneous accumulation throughout the brain
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2022.03.005
Abstract: Amyloid plaque aggregation is a pathologic hallmark of Alzheimer's disease (AD) that occurs early in the disease. However, little is known about its progression throughout the brain. Using Pittsburgh Compound B (PIB)-PET imaging, we investigated… read more here.
Keywords: pathology; amyloid accumulation; accumulation; rates amyloid ... See more keywords
Early Brain Amyloid Accumulation at PET in Military Instructors Exposed to Subconcussive Blast Injuries.
Sign Up to like & getrecommendations! Published in 2023 at "Radiology"
DOI: 10.1148/radiol.221608
Abstract: Background Traumatic brain injury (TBI) is the leading cause of disability in young adults. Recurrent TBI is associated with a range of neurologic sequelae, but the contributing factors behind the development of such chronic encephalopathy… read more here.
Keywords: control participants; blast; amyloid accumulation; brain ... See more keywords
Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia
Sign Up to like & getrecommendations! Published in 2021 at "Neurology"
DOI: 10.1212/wnl.0000000000011612
Abstract: Objective To examine whether early β–amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia. Methods We examined 54 volunteers (mean age 70.0 years, 56% women, 51% APOE ɛ4… read more here.
Keywords: early amyloid; amyloid accumulation; 11c pbr28; neuroinflammation ... See more keywords
Spatial-Temporal Patterns of β-Amyloid Accumulation
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200148
Abstract: Background and Objectives β-amyloid (Aβ) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation subtypes by applying the data-driven Subtype and Stage Inference (SuStaIn) model to amyloid-PET data.… read more here.
Keywords: parietal occipital; amyloid accumulation; subtype assignment; accumulation ... See more keywords
Spatial-Temporal Patterns of β-Amyloid Accumulation: A Subtype and Stage Inference Model Analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000201144
Abstract: Background and Objectives β -amyloid (A β ) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for A β accumulation subtypes by applying the data-driven Subtype and Stage Inference (SuStaIn)… read more here.
Keywords: amyloid accumulation; accumulation; subtype stage; spatial temporal ... See more keywords
MiR-144 promotes β-amyloid accumulation-induced cognitive impairments by targeting ADAM10 following traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19469
Abstract: The dysregulation expression of microRNAs (miRNAs) including miR-144, has been widely documented in TBI. However, little is known about the potential roles of miR-144 in the pathogenesis of TBI. In this study, we investigated the… read more here.
Keywords: adam10; cognitive impairments; induced cognitive; amyloid accumulation ... See more keywords