Suppression and dissolution of amyloid aggregates using ionic liquids
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Reviews"
DOI: 10.1007/s12551-018-0421-8
Abstract: Amyloid aggregates are composed of protein fibrils with a dominant β-sheet structure, are water-insoluble, and are involved in the pathogenesis of many neurodegenerative diseases. Development of pharmaceuticals to treat these diseases and the design of… read more here.
Keywords: amyloid aggregates; suppression dissolution; suppression; ionic liquids ... See more keywords
Near-Infrared-Active Copper Bismuth Oxide Electrodes for Targeted Dissociation of Alzheimer's β-Amyloid Aggregates.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c02349
Abstract: The abnormal accumulation of β-amyloid (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). We report near-infrared (NIR)-active CuBi2O4-based photocathodic platform that can target intact Aβ aggregates and dissociate them… read more here.
Keywords: cubi2o4; klvff cubi2o4; amyloid aggregates; near infrared ... See more keywords
In situ structural characterization of early amyloid aggregates in Alzheimer’s disease transgenic mice and Octodon degus
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62708-2
Abstract: Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer’s disease. In situ identification of early-stage amyloid aggregates in Alzheimer’s disease is relevant for their importance as potential targets… read more here.
Keywords: amyloid aggregates; alzheimer disease; transgenic mice; mice ... See more keywords
Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc09085k
Abstract: We present a reconstituted lipoprotein-based nanoparticle platform comprising a curcumin fluorescent motif and an NIR responsive gold core. This multifunctional nanosystem is successfully used for aggregation-dependent fluorescence detection and photothermal disassembly of insoluble amyloid aggregates. read more here.
Keywords: amyloid aggregates; detection photothermal; lipoprotein based; gold ... See more keywords
The interactions of amyloid β aggregates with phospholipid membranes and the implications for neurodegeneration.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20220434
Abstract: Misfolding, aggregation and accumulation of Amyloid-β peptides (Aβ) in neuronal tissue and extracellular matrix are hallmark features of Alzheimer's disease (AD) pathology. Soluble Aβ oligomers are involved in neuronal toxicity by interacting with the lipid… read more here.
Keywords: implications neurodegeneration; interactions amyloid; membranes implications; phospholipid membranes ... See more keywords
The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15842
Abstract: The accumulation of amyloidogenic protein aggregates in neurons is a pathogenic hallmark of a large number of neurodegenerative diseases including Alzheimer's disease (AD). Small molecules targeting such structures and promoting their degradation may have therapeutic… read more here.
Keywords: egcg directly; directly targets; amyloid aggregates; lysosomal degradation ... See more keywords
Amyloid Aggregates Are Localized to the Nonadherent Detached Fraction of Aging Streptococcus mutans Biofilms
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01661-22
Abstract: Streptococcus mutans is a keystone pathogen and causative agent of human dental caries, commonly known as tooth decay, the most prevalent infectious disease in the world. Like many pathogens, S. mutans causes disease in biofilms,… read more here.
Keywords: tooth decay; streptococcus mutans; streptococcus; amyloid aggregates ... See more keywords
In vivo targeting and multimodal imaging of cerebral amyloid-β aggregates using hybrid GdF3 nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Nanomedicine"
DOI: 10.2217/nnm-2022-0252
Abstract: Aim: To propose a new multimodal imaging agent targeting amyloid-β (Aβ) plaques in Alzheimer's disease. Materials & methods: A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with a pentameric luminescent-conjugated… read more here.
Keywords: targeting multimodal; multimodal imaging; vivo targeting; amyloid aggregates ... See more keywords
Optotracing for live selective fluorescence-based detection of Candida albicans biofilms
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.981454
Abstract: Candida albicans is the most common fungal pathogen in humans, implicated in hospital-acquired infections, secondary infections in human immunodeficiency virus (HIV) patients, and is a significant contributor to the global antimicrobial resistance (AMR) burden. Early… read more here.
Keywords: fungal biofilms; detection; amyloid aggregates; fluorescence ... See more keywords
The In Vitro Anti-amyloidogenic Activity of the Mediterranean Red Seaweed Halopithys Incurva
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13080185
Abstract: Neurodegenerative diseases are generally characterized by the presence of neurotoxic amyloid aggregates underlying progressive neuronal death. Since ancient times, natural compounds have been used as curative agents for human health. Amyloid research is constantly looking… read more here.
Keywords: amyloid aggregates; mediterranean red; red seaweed; incurva ... See more keywords