Amyloid-Beta Pathology and Cognitive Performance in Centenarians.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2025.1734
Abstract: Importance Older individuals without dementia often have amyloid-beta (Aβ) Thal phases similar to patients with Alzheimer disease (AD), suggesting that Aβ pathology may be a benign consequence of aging. Objective To explore whether Aβ pathology… read more here.
Keywords: performance centenarians; pathology; performance; amyloid beta ... See more keywords
Deep‐Learning‐Assisted Stratification of Amyloid Beta Mutants Using Drying Droplet Patterns
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202110404
Abstract: The development of simple and accurate methods to predict mutations in proteins remains an unsolved challenge in modern biochemistry. It is discovered that critical information about primary and secondary peptide structures can be inferred from… read more here.
Keywords: drying droplet; amyloid beta; deep learning; stratification ... See more keywords
The impact of amyloid‐beta and tau on prospective cognitive decline in older individuals
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25395
Abstract: Amyloid‐beta (Aβ) and tau pathologies are commonly observed among clinically normal older individuals at postmortem and can now be detected with in vivo neuroimaging. The association and interaction of these proteinopathies with prospective cognitive decline… read more here.
Keywords: prospective cognitive; amyloid beta; beta tau; older individuals ... See more keywords
A Unified View of Assessing the Pro‐oxidant versus Antioxidant Nature of Amyloid Beta Conformers
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800446
Abstract: Transition‐metal‐catalyzed oxidative stress is a widespread concern in the pathogenesis of Alzheimer's disease. However, the exact role of amyloid beta oligomers towards oxidative stress is widely debated. Assessing the oxidative nature of the oligomers in… read more here.
Keywords: amyloid beta; pro oxidant; unified view; nature ... See more keywords
Microglial Dysfunction Mediated by Pb and Amyloid Beta Peptides as a Possible Mechanism of Neurotoxicity
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4839
Abstract: This study delves into the inflammatory and degenerative impacts of lead (Pb) toxicity and amyloid beta peptides (Aβ‐peptide 1–40 and Aβ‐peptide 25–35) on brain cells, particularly by fostering M1 polarization in microglial cells and subsequent… read more here.
Keywords: dysfunction mediated; microglial dysfunction; amyloid beta; beta peptides ... See more keywords
Amyloid beta induces Fmr1‐dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30754
Abstract: Alzheimer's disease (AD) is the most common cause of dementia, with the accumulation of amyloid beta peptide (Aβ) being one of the main causes of the disease. Fragile X mental retardation protein (FMRP), encoded by… read more here.
Keywords: suppression hyposynchrony; amyloid beta; translational suppression; activity ... See more keywords
Resveratrol targeting tau proteins, amyloid‐beta aggregations, and their adverse effects: An updated review
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6732
Abstract: Resveratrol (Res) is a non‐flavonoid compound with pharmacological actions such as antioxidant, antiinflammatory, hepatoprotective, antidiabetes, and antitumor. This plant‐derived chemical has a long history usage in treatment of diseases. The excellent therapeutic impacts of Res… read more here.
Keywords: tau proteins; amyloid beta; resveratrol targeting; review ... See more keywords
Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, tau and alpha-synuclein
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-024-06806-7
Abstract: There is an unmet need for compounds to detect fibrillar forms of alpha-synuclein (αSyn) and 4-repeat tau, which are critical in many neurodegenerative diseases. Here, we aim to develop an efficient surface plasmon resonance (SPR)-based… read more here.
Keywords: tau; syn fibrils; amyloid beta; binding sites ... See more keywords
Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1868-1
Abstract: The gradual deterioration of cognitive functions in Alzheimer’s disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate that toxic oligomers of amyloid-beta may cause propagation of pathology in… read more here.
Keywords: alzheimer disease; amyloid beta; beta oligomers; pathology ... See more keywords
Amyloid-beta antibody treatment in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Wiener Klinische Wochenschrift"
DOI: 10.1007/s00508-024-02466-7
Abstract: Amyloid-beta (Aβ) antibody treatment has emerged as a promising approach for the treatment of Alzheimer’s disease (AD), targeting the accumulation of Aβ plaques, which are a hallmark of the disease. This review provides an update… read more here.
Keywords: treatment; antibody; treatment alzheimer; beta antibody ... See more keywords
Matrix metalloproteinase 14 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "Neurological Sciences"
DOI: 10.1007/s10072-017-3166-4
Abstract: Diabetes mellitus is associated with dementia, but whether diabetes is associated with Alzheimer’s disease remains controversial. Alzheimer’s disease is characterized by amyloid beta aggregation. We hypothesized that genes, involved in amyloid beta degradation, may be… read more here.
Keywords: matrix metalloproteinase; alzheimer disease; amyloid beta; disease ... See more keywords