Deep‐Learning‐Assisted Stratification of Amyloid Beta Mutants Using Drying Droplet Patterns
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202110404
Abstract: The development of simple and accurate methods to predict mutations in proteins remains an unsolved challenge in modern biochemistry. It is discovered that critical information about primary and secondary peptide structures can be inferred from… read more here.
Keywords: drying droplet; amyloid beta; deep learning; stratification ... See more keywords
The impact of amyloid‐beta and tau on prospective cognitive decline in older individuals
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25395
Abstract: Amyloid‐beta (Aβ) and tau pathologies are commonly observed among clinically normal older individuals at postmortem and can now be detected with in vivo neuroimaging. The association and interaction of these proteinopathies with prospective cognitive decline… read more here.
Keywords: prospective cognitive; amyloid beta; beta tau; older individuals ... See more keywords
A Unified View of Assessing the Pro‐oxidant versus Antioxidant Nature of Amyloid Beta Conformers
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DOI: 10.1002/cbic.201800446
Abstract: Transition‐metal‐catalyzed oxidative stress is a widespread concern in the pathogenesis of Alzheimer's disease. However, the exact role of amyloid beta oligomers towards oxidative stress is widely debated. Assessing the oxidative nature of the oligomers in… read more here.
Keywords: amyloid beta; pro oxidant; unified view; nature ... See more keywords
Amyloid beta induces Fmr1‐dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30754
Abstract: Alzheimer's disease (AD) is the most common cause of dementia, with the accumulation of amyloid beta peptide (Aβ) being one of the main causes of the disease. Fragile X mental retardation protein (FMRP), encoded by… read more here.
Keywords: suppression hyposynchrony; amyloid beta; translational suppression; activity ... See more keywords
Resveratrol targeting tau proteins, amyloid‐beta aggregations, and their adverse effects: An updated review
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DOI: 10.1002/ptr.6732
Abstract: Resveratrol (Res) is a non‐flavonoid compound with pharmacological actions such as antioxidant, antiinflammatory, hepatoprotective, antidiabetes, and antitumor. This plant‐derived chemical has a long history usage in treatment of diseases. The excellent therapeutic impacts of Res… read more here.
Keywords: tau proteins; amyloid beta; resveratrol targeting; review ... See more keywords
Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1868-1
Abstract: The gradual deterioration of cognitive functions in Alzheimer’s disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate that toxic oligomers of amyloid-beta may cause propagation of pathology in… read more here.
Keywords: alzheimer disease; amyloid beta; beta oligomers; pathology ... See more keywords
Matrix metalloproteinase 14 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "Neurological Sciences"
DOI: 10.1007/s10072-017-3166-4
Abstract: Diabetes mellitus is associated with dementia, but whether diabetes is associated with Alzheimer’s disease remains controversial. Alzheimer’s disease is characterized by amyloid beta aggregation. We hypothesized that genes, involved in amyloid beta degradation, may be… read more here.
Keywords: matrix metalloproteinase; alzheimer disease; amyloid beta; disease ... See more keywords
Abelson Kinases Mediate the Depression of Spontaneous Synaptic Activity Induced by Amyloid Beta 1–42 Peptides
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00858-7
Abstract: Amyloid beta (Aβ) peptides represent one of the most studied etiological factors of Alzheimer’s disease. Nevertheless, the effects elicited by different molecular forms of amyloid beta peptides widely vary between the studies, mostly depending on… read more here.
Keywords: kinase; amyloid beta; beta; beta peptides ... See more keywords
Isomerization of Aspartyl Residue in Amyloid Beta Fragments: The Kinetics by Real-Time 1H NMR Under Neutral and Basic Conditions
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Solution Chemistry"
DOI: 10.1007/s10953-020-01018-7
Abstract: Isomers of aspartyl (Asp) residues have been found in various proteins in aged human tissues. Isomerization of Asp is considered as one of the potential factors to facilitate amyloidosis via the oligomerization of amyloid beta… read more here.
Keywords: isomerization; isomerization aspartyl; amyloid beta; real time ... See more keywords
Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0446-1
Abstract: Alzheimer’s disease (AD) is characterized by progressive neuronal degeneration and pathological accumulation of amyloid plaques in the brain. It has been proposed that the prion-like spreading of amyloid beta (Aβ) protein could contribute to the… read more here.
Keywords: via neural; amyloid beta; neural connections; brain regions ... See more keywords
Avicularin Attenuates Memory Impairment in Rats with Amyloid Beta-Induced Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Neurotoxicity research"
DOI: 10.1007/s12640-021-00467-2
Abstract: Amyloid-beta-induced Alzheimer's disease (AD) and its further complications are well-established models in preclinical studies and demonstrated by many researchers. Intracerebroventricular injection of Aβ produces brain malfunction, including neurodegeneration and memory impairment. Avicularin is a bioactive… read more here.
Keywords: avicularin; beta induced; amyloid beta; alzheimer disease ... See more keywords