Chemical‐Driven Outflow of Dissociated Amyloid Burden from Brain to Blood
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DOI: 10.1002/advs.202104542
Abstract: Amyloid‐β (Aβ) deposition in the brain is a primary biomarker of Alzheimer's disease (AD) and Aβ measurement for AD diagnosis mostly depends on brain imaging and cerebrospinal fluid analyses. Blood Aβ can become a reliable… read more here.
Keywords: amyloid burden; brain; chemical; brain blood ... See more keywords
Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women
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DOI: 10.1002/ana.26417
Abstract: Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed inter‐relationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors… read more here.
Keywords: lifestyle affects; cognition; amyloid burden; burden cognition ... See more keywords
Associations of rest-activity patterns with amyloid burden, medial temporal lobe atrophy, and cognitive impairment
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102881
Abstract: Background We sought to investigate the possible associations of rest-activity patterns with cortical amyloid burden, medial temporal lobe (MTL) neurodegeneration, and cognitive function in patients in the early stage of cognitive impairment. Methods Rest-activity patterns… read more here.
Keywords: rest activity; amyloid burden; activity patterns; cognitive impairment ... See more keywords
AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model
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DOI: 10.1093/hmg/ddx056
Abstract: Gelsolin amyloidosis is a dominantly inherited, incurable type of amyloidosis. A single point mutation in the gelsolin gene (G654A is most common) results in the loss of a Ca2+ binding site in the second gelsolin… read more here.
Keywords: amyloid burden; gelsolin; bispecific nanobody; amyloidosis ... See more keywords
Related amyloid burden and cortical atrophy in individuals with subtle cognitive decline
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroimaging"
DOI: 10.1111/jon.13055
Abstract: Subtle cognitive decline represents a stage of cognitive deterioration in which pathological biomarkers may be present, including early cortical atrophy and amyloid deposition. Using individual items from the Montreal Cognitive Assessment and k‐modes cluster analysis,… read more here.
Keywords: subtle cognitive; cortical atrophy; amyloid burden; atrophy ... See more keywords
Association of Enlarged Perivascular Spaces With Amyloid Burden and Cognitive Decline in Alzheimer Disease Continuum
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DOI: 10.1212/wnl.0000000000200989
Abstract: Background and Objectives To investigate the effects of enlarged perivascular space (EPVS) on amyloid burden and cognitive function in Alzheimer disease (AD) continuum. Methods We retrospectively reviewed 208 patients with AD across the cognitive continuum… read more here.
Keywords: epvs; cso epvs; amyloid burden; disease ... See more keywords