Polyphenol‐solubility alters amyloid fibril formation of α‐synuclein
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4130
Abstract: Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Amyloid fibrils form above the solubility of amyloidogenic proteins or peptides upon breaking supersaturation, followed by a nucleation… read more here.
Keywords: formation synuclein; formation; fibril formation; solubility ... See more keywords
Understanding amyloid fibril formation using protein fragments: structural investigations via vibrational spectroscopy and solid-state NMR
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Reviews"
DOI: 10.1007/s12551-018-0427-2
Abstract: It is well established that amyloid proteins play a primary role in neurodegenerative diseases. Alzheimer’s, Parkinson’s, type II diabetes, and Creutzfeldt-Jakob’s diseases are part of a wider family encompassing more than 50 human pathologies related… read more here.
Keywords: solid state; formation; vibrational spectroscopy; amyloid fibril ... See more keywords
Diameter of the vial plays a crucial role in the amyloid fibril formation: Role of interface area between hydrophilic-hydrophobic surfaces.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.03.070
Abstract: Number of incurable diseases associated with neurodegenerative syndromes like Alzheimer's, and Parkinson's, are owing to protein aggregation which leads to amyloid fibril formation. In vitro, such fibrillation depends on concentration, temperature, pH, ionic strength, organic… read more here.
Keywords: fibrillation; fibril formation; diameter vial; role ... See more keywords
The effect of three polyphenols and some other antioxidant substances on amyloid fibril formation by Human cystatin C
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104806
Abstract: Human cystatin C (CysC) is an amyloid forming protein involved in the hereditary cerebral amyloid angiopathy (HCCAA) that affects arteries in the brain and the peripheral nervous system. In this study we measured the influence… read more here.
Keywords: human cystatin; effect; fibril formation; effect three ... See more keywords
Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00353
Abstract: The human molecular chaperone DNAJB6, an oligomeric protein with a conserved S/T-rich region, is an efficient suppressor of amyloid fibril formation by highly aggregation-prone peptides such as the Aβ and polyQ peptides associated with Alzheimer's… read more here.
Keywords: fibril formation; amyloid fibril; chaperone dnajb6; formation ... See more keywords
Targeting the amyloid-β fibril surface by constrained helical peptide inhibitor.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00800
Abstract: Amyloid-β (Aβ) oligomers are well-known toxic molecular species associated with Alzheimer's disease. Recent discoveries of the ability of amyloid fibril surfaces to convert soluble proteins into toxic oligomers suggested that these surfaces could serve as… read more here.
Keywords: helical peptide; surface; fibril surface; amyloid fibril ... See more keywords
Ultraeffective Inhibition of Amyloid Fibril Assembly by Nanobody-Gold Nanoparticle Conjugates.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00797
Abstract: Amyloid fibril assembly is associated with many human disorders, and to approach an inhibitor of amyloid formation that is effective at ultralow stoichiometric concentrations remains a big challenge. Taking fibril assembly of human islet amyloid… read more here.
Keywords: fibril assembly; inhibition; iapp; amyloid fibril ... See more keywords
High Internal Phase Emulsions Stabilized with Polyphenol-Amyloid Fibril Supramolecules for Encapsulation and Protection of Lutein.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c04615
Abstract: High internal phase emulsions (HIPEs), also called highly concentrated emulsions with a minimal internal phase volume fraction of 74%, have been paid increasing attention in the development of functional foods due to their high potential… read more here.
Keywords: high internal; microscopy; internal phase; encapsulation ... See more keywords
Differential Binding and Conformational Dynamics of Tau Microtubule-Binding Repeats with a Preformed Amyloid-β Fibril Seed.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00014
Abstract: Both senile plaques formed by amyloid-β (Aβ) and neurofibrillary tangles (NFTs) comprised of tau are pathological hallmarks of Alzheimer's disease (AD). The accumulation of NFTs better correlates with the loss of cognitive function than senile… read more here.
Keywords: microtubule binding; fibril seed; preformed amyloid; seed ... See more keywords
Sustainable Bioplastics from Amyloid Fibril-Biodegradable Polymer Blends
Sign Up to like & getrecommendations! Published in 2021 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.1c03937
Abstract: Plastic waste production is a global challenging problem since its accumulation in the environment is causing devastating effects on the planet's ecosystem. Sustainable and green solutions are urgently needed, and this pairs with increasingly stronger… read more here.
Keywords: fibril biodegradable; sustainable bioplastics; biodegradable polymer; bioplastics amyloid ... See more keywords
Inhibition of amyloid fibril formation of β-lactoglobulin by natural and synthetic curcuminoids
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj03194k
Abstract: The aggregation of proteins has been associated with several aspects of daily life, including food processing, blood coagulation and many neurodegenerative infections. However, the actual mechanisms responsible for amyloidosis, the irreversible fibril formation of various… read more here.
Keywords: inhibition amyloid; formation; fibril formation; amyloid fibril ... See more keywords