The role of amyloidogenic proteins as a meeting point of type 2 diabetes and Parkinson's disease pathways
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26897
Abstract: The impairment of amyloid formation is associated with Parkinson disease (PD) and type 2 diabetes (T2D) in which the primary pathological characteristics are assembly of asynuclein into amyloid fiber and islet amyloid polypeptide (IAPP) formation… read more here.
Keywords: aggregation; disease; formation; pro iapp ... See more keywords
Polyphenol‐solubility alters amyloid fibril formation of α‐synuclein
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4130
Abstract: Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Amyloid fibrils form above the solubility of amyloidogenic proteins or peptides upon breaking supersaturation, followed by a nucleation… read more here.
Keywords: formation synuclein; formation; fibril formation; solubility ... See more keywords
Mechanism of rutin mediated inhibition of insulin amyloid formation and protection of Neuro-2a cells from fibril-induced apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05393-8
Abstract: Many metabolic and neurodegenerative diseases are associated with protein misfolding and aggregation. Insulin a key hormone, under certain conditions aggregates and forms pathological amyloid fibrils. Several polyphenols have been studied extensively to elucidate their inhibitory… read more here.
Keywords: insulin; fibril induced; insulin amyloid; rutin ... See more keywords
Shear-induced amyloid formation of IDPs in the brain.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.05.008
Abstract: The IDP amyloid β-protein (Aβ) has been both the prime causative suspect and drug development target in the fight against Alzheimer's disease (AD). Unfortunately, all clinical trials against Aβ based on this assumption have failed.… read more here.
Keywords: induced amyloid; shear induced; induced aggregation; amyloid formation ... See more keywords
Thioflavin T fluorescence to analyse amyloid formation kinetics: Measurement frequency as a factor explaining irreproducibility.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2017.06.007
Abstract: The most frequent method to monitor amyloid formation relies on the fluorescence of thioflavin T (ThT). The present study reports a novel factor of irreproducibility in ThT kinetic assays performed in microplate. Discrepancies among kinetics… read more here.
Keywords: fluorescence; frequency; irreproducibility; factor ... See more keywords
Cross-Reactivity of Alpha-Synuclein with Other Cellular Components Can Dramatically Modulate Amyloid Formation
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1980
Abstract: The aggregation process, going from monomers to amyloid fibers, of the protein α-synuclein (αS) somehow causes degeneration of dopaminergic neurons in Parkinson's disease patients. The exact activities of αS are not yet identified, but synapse… read more here.
Keywords: cross reactivity; modulate amyloid; formation; parkinson disease ... See more keywords
Ribosylation induced structural changes in Bovine Serum Albumin: understanding high dietary sugar induced protein aggregation and amyloid formation
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e05053
Abstract: Non-enzymatic glycation of proteins is believed to be the root cause of high dietary sugar associated pathophysiological maladies. We investigated the structural changes in protein during progression of glycation using ribosylated Bovine Serum Albumin (BSA).… read more here.
Keywords: formation; ribosylation; glycation; dietary sugar ... See more keywords
The Process of Amyloid Formation due to Monoclonal Immunoglobulins.
Sign Up to like & getrecommendations! Published in 2020 at "Hematology/oncology clinics of North America"
DOI: 10.1016/j.hoc.2020.07.003
Abstract: Monoclonal antibodies secreted by clonally expanded plasma cells can form a range of pathologic aggregates including amyloid fibrils. The enormous diversity in the sequences of the involved light chains may be responsible for complexity of… read more here.
Keywords: process amyloid; formation due; amyloid fibrils; monoclonal immunoglobulins ... See more keywords
Correct partner makes the difference: Septin G-interface plays a critical role in amyloid formation.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.04.105
Abstract: Septins are members of a group of GTP-binding proteins highly conserved in eukaryotes, being linked to diverse cell processes, such as cytokinesis and membrane association. On the other hand, the malfunction of septins is linked… read more here.
Keywords: critical role; formation; interface; amyloid formation ... See more keywords
Likelihood of amyloid formation in COVID-19-induced ARDS
Sign Up to like & getrecommendations! Published in 2021 at "Trends in Microbiology"
DOI: 10.1016/j.tim.2021.03.008
Abstract: Severe coronavirus disease 2019 (COVID-19) infection leads to multifactorial acute respiratory distress syndrome (ARDS), with little therapeutic success. The pathophysiology associated with ARDS or post-ARDS is not yet well understood. We hypothesize that amyloid formation… read more here.
Keywords: induced ards; likelihood amyloid; covid; amyloid formation ... See more keywords
Differential Effects of Aromatic Residues on Amyloid Formation and Cytotoxicity of Human IAPP.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00267
Abstract: Islet amyloid polypeptide (IAPP) is a 37-residue polypeptide hormone secreted by the pancreatic β-cells. IAPP plays a role in glycemic regulation, but in the pre-type-2 diabetic state, it aggregates to form an islet amyloid. The… read more here.
Keywords: amyloid formation; aromatic residues; role; formation cytotoxicity ... See more keywords