WALTZ-DB 2.0: an updated database containing structural information of experimentally determined amyloid-forming peptides
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz758
Abstract: Abstract Transition of soluble proteins into insoluble amyloid fibrils is driven by self-propagating short sequence stretches. However, accurate prediction of aggregation determinants remains challenging. Here, we describe WALTZ-DB 2.0, an updated and significantly expanded open-access… read more here.
Keywords: information; information experimentally; determined amyloid; experimentally determined ... See more keywords
Bloodborne Pancreatic Amylin, A Therapeutic Target for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Current Alzheimer research"
DOI: 10.2174/1567205020666230217091540
Abstract: Alzheimer Disease (AD) pathology has been linked to brain accumulation of β amyloid (Aβ) and neurofibrillary tau tangles. An intriguing question is whether targeting therapeutically factors independent of Aβ and tau pathologies could delay or… read more here.
Keywords: alzheimer disease; bloodborne pancreatic; pathology; amylin ... See more keywords
On the Conformational Dynamics of β-Amyloid Forming Peptides: A Computational Perspective
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00532
Abstract: Understanding the conformational dynamics of proteins and peptides involved in important functions is still a difficult task in computational structural biology. Because such conformational transitions in β-amyloid (Aβ) forming peptides play a crucial role in… read more here.
Keywords: forming peptides; conformational dynamics; peptides computational; dynamics amyloid ... See more keywords
Assessing Als3 Peptide-Binding Cavity and Amyloid-Forming Region Contributions to Candida albicans Invasion of Human Oropharyngeal Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.890839
Abstract: Although it is widely recognized that disruption of ALS3 reduces the invasion of Candida albicans germ tubes into mammalian oral epithelial cells, the mechanism of this interaction was unexplored. C. albicans strains with structurally informed… read more here.
Keywords: binding cavity; peptide binding; invasion; epithelial cells ... See more keywords
The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1104662
Abstract: Chronic kidney disease (CKD) is increasing worldwide and is associated with diabetic states (obesity, prediabetes and type-2 diabetes mellitus). The kidney is intrinsically susceptible to low oxygen (hypoxia) and renal hypoxia plays a vital role… read more here.
Keywords: renal accumulation; renal hypoxia; hypoxia; forming amylin ... See more keywords
Assessment of Amyloid Forming Tendency of Peptide Sequences from Amyloid Beta and Tau Proteins Using Force-Field, Semi-Empirical, and Density Functional Theory Calculations
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063244
Abstract: A wide variety of neurodegenerative diseases are characterized by the accumulation of protein aggregates in intraneuronal or extraneuronal brain regions. In Alzheimer’s disease (AD), the extracellular aggregates originate from amyloid-β proteins, while the intracellular aggregates… read more here.
Keywords: force field; peptide sequences; sequences amyloid; theory calculations ... See more keywords