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Published in 2018 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2017.2558
Abstract: Accumulating evidence indicates that the pathophysiological process underlying Alzheimer disease—including protein aggregation, synaptic dysfunction, and neuronal loss—begins years if not decades prior to the onset of clinical symptoms and functional limitation. This long prodromal period…
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Keywords:
neurology;
alzheimer disease;
study;
disease ... See more keywords
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Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac030
Abstract: Senile plaques have been studied in postmortem brains for more than 120 years and the resultant knowledge has not only helped us understand the etiology and pathogenesis of Alzheimer disease (AD), but has also pointed to…
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Keywords:
senile plaques;
plaques alzheimer;
alzheimer amyloid;
amyloid imaging ... See more keywords
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Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1063598
Abstract: Background Amyloid-β (Aβ) accumulation is considered the earliest pathological change in Alzheimer's disease (AD). The Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) consortium is a collaborative European framework across European Federation of Pharmaceutical Industries Associations…
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Keywords:
consortium;
alzheimer disease;
amyloid imaging;
methodology ... See more keywords