Cannabinoids prevent the amyloid β‐induced activation of astroglial hemichannels: A neuroprotective mechanism
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DOI: 10.1002/glia.23080
Abstract: The mechanisms involved in Alzheimer's disease are not completely understood and how astrocytes and their gliotransmission contribute to this neurodegenerative disease remains to be fully elucidated. Previous studies have shown that amyloid‐β peptide (Aβ) induces… read more here.
Keywords: hemichannel activity; mechanism; hemichannel; amyloid induced ... See more keywords
Dehydroeffusol Rescues Amyloid β25–35-Induced Spatial Working Memory Deficit
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DOI: 10.1007/s11130-020-00816-0
Abstract: Amyloid β (Aβ) peptides produced from the amyloid precursor protein, a transmembrane protein, are neurotoxic and blocking the neurotoxicity may lead to prevention of Alzheimer’s disease (AD). Here we tested whether Aβ25–35-induced cognitive decline is… read more here.
Keywords: rescues amyloid; dehydroeffusol rescues; dehydroeffusol; amyloid induced ... See more keywords
Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline
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DOI: 10.1016/j.celrep.2018.11.098
Abstract: Alzheimer's disease (AD) is the most common form of dementia, impairing cognitive and motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not reflected in mouse models of AD. Therefore,… read more here.
Keywords: cognitive motor; less fit; amyloid induced; motor ... See more keywords
Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis
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DOI: 10.1038/srep40744
Abstract: Eugenol has attracted considerable attention because of its potential for many pharmaceutical applications including anti-inflammatory, anti-tumorigenic and anti-oxidant properties. Here, we have investigated the effect of eugenol on amyloid formation of selected globular proteins. We… read more here.
Keywords: eugenol; amyloid induced; amyloid formation; induced hemolysis ... See more keywords
Evaluation of structure–activity relationships of ginsenosides against amyloid β induced pathological behaviours in transgenic Caenorhabditis elegans
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DOI: 10.1039/c7ra05717b
Abstract: Amyloid β (Aβ) induced toxicity has been postulated to initiate synaptic loss and subsequent neuronal degeneration in Alzheimer's disease (AD). The activities of ginsenosides against AD are widely reported, however, a systematic in vivo study… read more here.
Keywords: activity relationships; transgenic caenorhabditis; caenorhabditis elegans; amyloid induced ... See more keywords
LncRNA Rpph1 protects amyloid-β induced neuronal injury in SK-N-SH cells via miR-122/Wnt1 axis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2019.1692834
Abstract: Abstract Objective: To investigate the role of lncRNA Rpph1 on amyloid-β induced neuronal injury in SK-N-SH cells and underlying mechanism. Methods: In vitro Alzheimer’s disease (AD) model was established using the SK-N-SH cells treated with… read more here.
Keywords: induced neuronal; lncrna rpph1; amyloid induced; rpph1 ... See more keywords
Roles of receptor‐interacting protein kinase 1 in SH‐SY5Y cells with beta amyloid‐induced neurotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17095
Abstract: Alzheimer's disease (AD), the major cause of dementia, affects the elderly population worldwide. Previous studies have shown that depletion of receptor‐interacting protein kinase 1 (RIPK1) expression reverted the AD phenotype in murine AD models. Necroptosis,… read more here.
Keywords: beta amyloid; receptor interacting; protein kinase; interacting protein ... See more keywords
Neuroprotective Effect of Stearidonic Acid on Amyloid β-Induced Neurotoxicity in Rat Hippocampal Cells
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DOI: 10.3390/antiox11122357
Abstract: Dietary intake of omega-3 fatty acids found in fish has been reported to reduce the risk of Alzheimer’s Disease (AD). Stearidonic acid (SDA), a plant-based omega-3 fatty acid, has been targeted as a potential surrogate… read more here.
Keywords: sda; amyloid induced; effect; hippocampal cells ... See more keywords
Modulation of Amyloid β-Induced Microglia Activation and Neuronal Cell Death by Curcumin and Analogues
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DOI: 10.3390/ijms23084381
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is not restricted to the neuronal compartment but includes important interactions with immune cells, including microglia. Protein aggregates, common pathological hallmarks of AD, bind to pattern… read more here.
Keywords: cell death; cell; amyloid induced; curcumin ... See more keywords
The Role of Aldose Reductase in Beta-Amyloid-Induced Microglia Activation
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DOI: 10.3390/ijms232315088
Abstract: The occurrence of Alzheimer’s disease has been associated with the accumulation of beta-amyloid (β-amyloid) plaques. These plaques activate microglia to secrete inflammatory molecules, which damage neurons in the brain. Thus, understanding the underlying mechanism of… read more here.
Keywords: role; beta amyloid; amyloid induced; microglia activation ... See more keywords
VANL-100 Attenuates Beta-Amyloid-Induced Toxicity in SH-SY5Y Cells
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DOI: 10.3390/ijms24010442
Abstract: Antioxidants are being explored as novel therapeutics for the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD) through strategies such as chemically linking antioxidants to synthesize novel co-drugs. The main objective of this study… read more here.
Keywords: sy5y cells; amyloid induced; vanl 100; induced toxicity ... See more keywords