[99mTc]Tc-hydroxydiphosphonate uptake in soft tissue is associated with amyloid load in subcutaneous abdominal fat tissue and mortality in wild-type transthyretin amyloidosis patients
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-024-06865-w
Abstract: Bone scintigraphy is key to non-invasively diagnosing wild-type transthyretin (ATTRwt) amyloidosis, and is mainly used to assess cardiac radiotracer uptake. However, extracardiac radiotracer uptake is also observed. We investigated whether intensity of soft tissue radiotracer… read more here.
Keywords: amyloid load; mortality; tissue; amyloidosis patients ... See more keywords
Cognitive changes of older adults with an equivocal amyloid load
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DOI: 10.1007/s00415-019-09203-5
Abstract: BackgroundObservational and interventional studies addressing the link between amyloid (Aβ) burden and cognitive decline are increasing, but a clear definition of amyloid positivity is still lacking. This may represent a great stake for therapeutic studies… read more here.
Keywords: equivocal amyloid; amyloid load; equivocal participants; older adults ... See more keywords
Treatment by low-dose brain radiation therapy improves memory performances without changes of the amyloid load in the TgF344-AD rat model
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2021.03.008
Abstract: Alzheimer's disease (AD) is a neurodegenerative condition affecting memory performance. This pathology is characterized by intracerebral amyloid plaques and tau tangles coupled with neuroinflammation. During the last century, numerous therapeutic trials unfortunately failed highlighting the… read more here.
Keywords: low dose; treatment; amyloid load; pathology ... See more keywords
Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia
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DOI: 10.1111/ene.16436
Abstract: This study evaluated associations of brain amyloid with 2‐year objective and subjective cognitive measures in a trial‐ready older general population at risk for dementia. read more here.
Keywords: amyloid load; subjective memory; risk dementia; load subjective ... See more keywords
Clinical and MRI Correlates of β‐Amyloid Load Inconsistent With Its Presumed Neurotoxicity in Cognitively Healthy Ageing
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DOI: 10.1111/jnc.70241
Abstract: Cognitively healthy ageing and its conceptual counterpart, dementia, have long garnered much interest in the research community, the broader public and regulatory bodies alike. Although β‐amyloid deposition is widely regarded as the principal neuropathological hallmark… read more here.
Keywords: neurotoxicity; amyloid load; cognitively healthy; mri ... See more keywords
β-Amyloid Load on PET Along the Continuum of Dementia With Lewy Bodies.
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DOI: 10.1212/wnl.0000000000207393
Abstract: BACKGROUND Amyloid-β plaques can co-occur with Lewy-related pathology in patients with dementia with Lewy bodies (DLB), but amyloid-β load at prodromal stages of DLB still needs to be elucidated. We investigated amyloid-β load on PET… read more here.
Keywords: dlb; lewy bodies; dlb continuum; continuum ... See more keywords
Relationship between salivary lactoferrin level and brain amyloid load in periodontal and non-periodontal subjects.
Sign Up to like & getrecommendations! Published in 2025 at "Medicina oral, patologia oral y cirugia bucal"
DOI: 10.4317/medoral.27612
Abstract: Background Lactoferrin in saliva has been proposed as a possible diagnostic biomarker for Alzheimer's disease, as it is associated with ß-amyloid load in the brain. The aim of this study was to find out whether… read more here.
Keywords: disease; amyloid load; brain; salivary lactoferrin ... See more keywords