Serum amyloid A1 mediates myotube atrophy via Toll‐like receptors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12491
Abstract: Critically ill patients frequently develop muscle atrophy and weakness in the intensive‐care‐unit setting [intensive care unit‐acquired weakness (ICUAW)]. Sepsis, systemic inflammation, and acute‐phase response are major risk factors. We reported earlier that the acute‐phase protein… read more here.
Keywords: myotube atrophy; muscle; amyloid mediates; mediates myotube ... See more keywords
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.01.031
Abstract: Mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to increased Alzheimer's disease (AD) risk. Neurobiological functions of TREM2 and its pathophysiological ligands remain elusive. Here we found that TREM2 directly… read more here.
Keywords: microglial function; mediates microglial; amyloid mediates; receptor amyloid ... See more keywords