Amyloid-mimicking toxic nanofibers generated via self-assembly of dopamine.
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DOI: 10.1039/d1nr07741d
Abstract: Molecular self-assembly of biologically relevant aromatic metabolites is known to generate cytotoxic nanostructures and this unique property has opened up new concepts in the molecular mechanisms of metabolite-linked disorders. Because aromaticity is intrinsic to the… read more here.
Keywords: self assembly; amyloid mimicking; dopamine; toxic nanofibers ... See more keywords
Tryptophan self-assembly yields cytotoxic nanofibers containing amyloid-mimicking and cross-seeding competent conformers.
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DOI: 10.1039/d2nr03544h
Abstract: Dietary consumption of Trp via protein-based foods is essential for the maintenance of crucial metabolic processes including the synthesis of proteins and several vital metabolites such as serotonin, melatonin, acetyl CoA, and NADP. However, the… read more here.
Keywords: competent conformers; seeding competent; self assembly; amyloid mimicking ... See more keywords