Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2016.10.012
Abstract: BACKGROUND Amyloid-β oligomers (AβO) are species mainly involved in the synaptic and cognitive dysfunction in Alzheimer's disease. Although their action has been described mainly at neuronal level, it is now clear that glial cells govern… read more here.
Keywords: establishment; activation; receptor; amyloid oligomers ... See more keywords
Targeting Hsc70-based autophagy to eliminate amyloid β oligomers.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.016
Abstract: Amyloid β (Aβ) oligomers may be a real culprit in the pathogenesis of Alzheimer's disease (AD); therefore, the elimination of these toxic oligomers may be of great significance for AD therapy. Autophagy is the catabolic… read more here.
Keywords: based autophagy; cma motifs; targeting hsc70; amyloid oligomers ... See more keywords
Exploring amyloid oligomers with peptide model systems.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.05.004
Abstract: The assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is directly linked to amyloid diseases, such as Alzheimer's, Parkinson's, and… read more here.
Keywords: peptide model; peptides proteins; model systems; amyloidogenic peptides ... See more keywords
Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02134
Abstract: RNA aptamers have garnered attention for diagnostic applications due to their ability to recognize diverse targets. Oligomers of 42-mer amyloid β-protein (Aβ42), whose accumulation is relevant to the pathology of Alzheimer’s disease (AD), are among… read more here.
Keywords: detection amyloid; rna aptamers; alzheimer disease; oligomers rna ... See more keywords
Small molecule-mediated co-assembly of amyloid-β oligomers reduces neurotoxicity through promoting non-fibrillar aggregation†
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc00392a
Abstract: Amyloid-β (Aβ) oligomers, particularly low molecular weight (LMW) oligomers, rather than fibrils, contribute very significantly to the onset and progression of Alzheimer's Disease (AD). However, due to the inherent heterogeneity and metastability of oligomers, most… read more here.
Keywords: mediated assembly; small molecule; non fibrillar; molecule mediated ... See more keywords
Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a024075
Abstract: In Alzheimer's disease (AD), insoluble and fibrillary amyloid-β (Aβ) peptide accumulates in plaques. However, soluble Aβ oligomers are most potent in creating synaptic dysfunction and loss. Therefore, receptors for Aβ oligomers are hypothesized to be… read more here.
Keywords: sites amyloid; toxicity; binding sites; oligomers synaptic ... See more keywords
Amyloid‐β oligomers in cellular models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15030
Abstract: Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to plaque formation, Aβ aggregates into non‐fibrillar soluble oligomers… read more here.
Keywords: alzheimer disease; cellular models; oligomers cellular; amyloid oligomers ... See more keywords
Sleep inhibition induced by amyloid‐β oligomers is mediated by the cellular prion protein
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Sleep Research"
DOI: 10.1111/jsr.13187
Abstract: Sleep is severely impaired in patients with Alzheimer's disease. Amyloid‐β deposition in the brain of Alzheimer's disease patients is a key event in its pathogenesis and is associated with disrupted sleep, even before the appearance… read more here.
Keywords: amyloid oligomers; mediated cellular; prion protein; cellular prion ... See more keywords
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1006962
Abstract: Impairment of the autophagy pathway has been observed during the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disorder characterized by abnormal deposition of extracellular and intracellular amyloid β (Aβ) peptides. Yet the role of autophagy… read more here.
Keywords: becn1; alzheimer disease; autophagy; amyloid oligomers ... See more keywords
An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22115991
Abstract: Amyloid-β (Aβ) 1-40 and 1-42 peptides are key mediators of synaptic and cognitive dysfunction in Alzheimer’s disease (AD). Whereas in AD, Aβ is found to act as a pro-epileptogenic factor even before plaque formation, amyloid… read more here.
Keywords: transmission cause; cause consequence; consequence amyloid; synaptic transmission ... See more keywords
Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22126355
Abstract: A large body of clinical and nonclinical evidence supports the role of neurotoxic soluble beta amyloid (amyloid, Aβ) oligomers as upstream pathogenic drivers of Alzheimer’s disease (AD). Recent late-stage trials in AD that have evaluated… read more here.
Keywords: oligomers drive; neurotoxic soluble; disease progression; amyloid oligomers ... See more keywords