Alzheimer's disease and late-onset epilepsy of unknown origin: two faces of beta amyloid pathology
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.09.006
Abstract: Although amyloid pathology plays a role in epilepsy, little is known about the relationship between beta amyloid and progression to Alzheimer's disease (AD) among patients with late-onset epilepsy of unknown origin (LOEU). This multicenter, observational,… read more here.
Keywords: late onset; alzheimer disease; onset epilepsy; beta amyloid ... See more keywords
Preclinical amyloid pathology biomarker positivity: effects on tau pathology and neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Translational Psychiatry"
DOI: 10.1038/tp.2016.252
Abstract: Brain autopsy and biomarker studies indicate that the pathology of Alzheimer’s disease (AD) is initiated at least 10–20 years before clinical symptoms. This provides a window of opportunity to initiate preventive treatment. However, this emphasizes… read more here.
Keywords: tau; biomarker; csf; pathology ... See more keywords
G protein–biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer’s disease mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204828119
Abstract: Significance Levels of the orphan G protein–coupled receptor GPR3 are elevated in a subset of patients with Alzheimer’s disease (AD). Our group previously showed that genetic deletion of Gpr3 attenuates amyloid-β (Aβ) pathology in multiple… read more here.
Keywords: amyloid pathology; alzheimer disease; pathology; biased gpr3 ... See more keywords
Knockout of apolipoprotein A‐I decreases parenchymal and vascular β‐amyloid pathology in the Tg2576 mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12556
Abstract: Apolipoprotein A‐I (apoA‐I), the principal apolipoprotein associated with high‐density lipoproteins in the periphery, is also found at high concentrations in the cerebrospinal fluid. Previous studies have reported either no impact or vascular‐specific effects of apoA‐I… read more here.
Keywords: apolipoprotein decreases; knockout apolipoprotein; pathology; decreases parenchymal ... See more keywords
A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq0095
Abstract: Triggering receptor expressed on myeloid cells 2 (TREM2) plays crucial roles in Alzheimer’s disease (AD) by regulating microglia migration toward, and phagocytosis of oligomeric amyloid-β (oAβ) and amyloid plaques. Studies in rodent models of AD… read more here.
Keywords: trem2; amyloid pathology; alzheimer disease; trem2 agonistic ... See more keywords
Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1473-9
Abstract: BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by the deposition of extracellular fibrillar amyloid β (fΑβ) and the intracellular accumulation of neurofibrillary tangles. As AD progresses, Aβ drives a robust and prolonged… read more here.
Keywords: model mice; microglial cell; disease; pathology ... See more keywords
Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01938-7
Abstract: Background Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer’s disease (AD) in elderly populations. While dietary supplementation of B-vitamins is a generally effective method to lower homocysteine levels, there… read more here.
Keywords: alzheimer disease; pathology; knock mouse; hyperhomocysteinemia ... See more keywords
Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-019-0315-7
Abstract: BackgroundBased on epidemiological and experimental studies, type 2 diabetes mellitus (T2DM), especially insulin resistance that comprises the core mechanism of T2DM, has been recognized as a significant risk factor for Alzheimer’s disease (AD). Studies in… read more here.
Keywords: insulin; pathology; insulin resistance; brain ... See more keywords
Comment: β-Amyloid pathology and Parkinson disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurology"
DOI: 10.1212/wnl.0000000000004756
Abstract: Recent evidence from histopathologic, CSF, and amyloid PET studies show that β-amyloid (Aβ) pathology is also involved in the pathophysiology of Parkinson disease (PD), correlating with a more rapid cognitive decline and predicting progression in… read more here.
Keywords: comment amyloid; pathology; pathology parkinson; parkinson disease ... See more keywords
Perturbed mitochondria-ER contacts in live neurons modelling Alzheimer's disease amyloid pathology.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cell science"
DOI: 10.1242/jcs.229906
Abstract: Reports using fixed fibroblasts from familial and sporadic Alzheimer's disease (AD) patients indicated upregulated mitochondria-endoplasmic reticulum contacts (MERC) as a hallmark of AD. Despite its potential significance, the relevance of these results is limited because… read more here.
Keywords: alzheimer disease; pathology; live neurons; merc ... See more keywords
Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263332
Abstract: Dysregulation of calcium homeostasis has been hypothesized to play a role in Alzheimer’s disease (AD) pathogenesis. Increased calcium levels can impair axonal transport, disrupt synaptic transmission, and ultimately lead to cell death. Given the potential… read more here.
Keywords: calcium; amyloid pathology; neuritic dystrophy; pathology ... See more keywords