The Amyloid-β Pathway in Alzheimer’s Disease
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DOI: 10.1038/s41380-021-01249-0
Abstract: Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer’s disease (AD) pathophysiology. While the detailed molecular mechanisms of the pathway and the spatial-temporal dynamics leading to synaptic failure, neurodegeneration,… read more here.
Keywords: medicine; alzheimer disease; pathway alzheimer; disease ... See more keywords
Role of Intracellular Amyloid β as Pathway Modulator, Biomarker, and Therapy Target
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094656
Abstract: The β- and γ-secretase-driven cleavage of the amyloid precursor protein (APP) gives rise to the amyloid β peptide, which is believed to be the main driver of neurodegeneration in Alzheimer’s disease (AD). As it is… read more here.
Keywords: pathway modulator; modulator biomarker; role; intracellular amyloid ... See more keywords