Autophagy impairment by caspase‐1‐dependent inflammation mediates memory loss in response to β‐Amyloid peptide accumulation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24130
Abstract: β‐Amyloid peptide accumulation in the cortex and in the hippocampus results in neurodegeneration and memory loss. Recently, it became evident that the inflammatory response triggered by β‐Amyloid peptides promotes neuronal cell death and degeneration. In… read more here.
Keywords: accumulation; memory loss; amyloid peptide; response ... See more keywords
Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β‐amyloid peptide (25–35)‐induced memory impairment in mice
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12292
Abstract: We previously reported that oxytocin, a peptide hormone, can reverse the β‐amyloid peptide (25–35) (Aβ25–35)‐induced impairments of the murine hippocampal synaptic plasticity. In this study, we examined the effects of oxytocin on the Aβ25–35‐induced impairment… read more here.
Keywords: administration; intracerebroventricular administration; amyloid peptide; administration oxytocin ... See more keywords
The Beneficial Role of Exercise on Treating Alzheimer's Disease by Inhibiting β-Amyloid Peptide.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02514-7
Abstract: Alzheimer's disease (AD) is associated with a very large burden on global healthcare systems. Thus, it is imperative to find effective treatments of the disease. One feature of AD is the accumulation of neurotoxic β-amyloid… read more here.
Keywords: alzheimer disease; exercise; amyloid peptide; role exercise ... See more keywords
Multivalent interacting glycodendrimer to prevent amyloid-peptide fibril formation induced by Cu(II): A multidisciplinary approach
Sign Up to like & getrecommendations! Published in 2018 at "Nano Research"
DOI: 10.1007/s12274-017-1734-9
Abstract: Amyloid peptide fibrillogenesis induced by Cu(II) ions is a key event in the pathogenesis of Alzheimer’s disease. Dendrimers have been found to be active in preventing fibril formation. Therefore, they hold promise for the treatment… read more here.
Keywords: amyloid peptide; glycodendrimer; formation; formation induced ... See more keywords
In search of pathogenic amyloid β-peptide in familial Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.07.002
Abstract: Early-onset familial Alzheimer's disease (FAD) is pathologically and clinically similar to the more common late-onset sporadic form of the disease. The study of rare genetic mutations that cause FAD should provide insight into the pathogenesis… read more here.
Keywords: alzheimer disease; familial alzheimer; amyloid peptide; disease ... See more keywords
Effect of tert-alcohol functional imidazolium salts on oligomerization and fibrillization of amyloid β (1-42) peptide.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2020.106480
Abstract: Imidazolium based IL's has gained vast interest in developing biological applications. Oligomerization and fibrillization of amyloid β (1-42) peptide are mainly responsible for the extra-neuronal deposition of amyloid fibrils in neurodegenerative disorders like Alzheimer's disease… read more here.
Keywords: peptide; amyloid peptide; oligomerization fibrillization; fibrillization amyloid ... See more keywords
Imaging Flow Cytometry Illuminates New Dimensions of Amyloid Peptide-Membrane Interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.01.018
Abstract: Membrane interactions of amyloidogenic proteins constitute central determinants both in protein aggregation as well as in amyloid cytotoxicity. Most reported studies of amyloid peptide-membrane interactions have employed model membrane systems combined with application of spectroscopy… read more here.
Keywords: amyloid peptide; imaging flow; 106 126; flow cytometry ... See more keywords
Reaction between the Pt(II)-complexes and the amino acids of the β-amyloid peptide
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2016.11.025
Abstract: Abstract Reaction between [Pt(ophen)Cl2] and HIS was monitored and the solvolysis ( k 1 ) and Cl/HIS ligand exchange ( k 2 ) rate constants obtained. The k 1 and k 2 were (6.2 ± 0.4) × 10−5 s−1 and… read more here.
Keywords: amyloid peptide; amino acids; reaction complexes; acids amyloid ... See more keywords
β-Amyloid peptide interactions with biomimetic membranes: A multiparametric characterization.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.03.107
Abstract: Alzheimer's disease is the most common form of senile dementia in the world, and amyloid β peptide1-42 (Aβ1-42) is one of its two principal biological hallmarks. While interactome concept was getting forward the scientific community,… read more here.
Keywords: multiparametric characterization; amyloid peptide; peptide interactions; biomimetic membranes ... See more keywords
Functional interplay between plasma membrane Ca2+-ATPase, amyloid β-peptide and tau
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.08.004
Abstract: It is well known that dysregulation of Ca2+ homeostasis is involved in Alzheimeŕs disease (AD), a neurodegenerative disorder characterized by the presence of toxic aggregates of amyloid β-peptide (Aβ) and neurofibrillary tangles of tau. Alteration… read more here.
Keywords: amyloid peptide; ca2 atpase; ca2; membrane ca2 ... See more keywords
Alzheimer's Drug PBT2 Interacts with the Amyloid β 1-42 Peptide Differently than Other 8-Hydroxyquinoline Chelating Drugs.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c01694
Abstract: Although Alzheimer's disease (AD) was first described over a century ago, it remains the leading cause of age-related dementia. Innumerable changes have been linked to the pathology of AD; however, there remains much discord regarding… read more here.
Keywords: pbt2 interacts; amyloid peptide; pathology; pbt2 ... See more keywords